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Granulocyte colony-stimulating factor induces sensorimotor recovery in intracerebral hemorrhage

Cited 63 time in Web of Science Cited 68 time in Scopus
Authors
Park, Hee-Kwon; Chu, Kon; Lee, Soon-Tae; Jung, Keun-Hwa; Kim, Eun-Hee; Lee, Kyung-Bok; Song, Young-Mok; Jeong, Sang-Wuk; Kim, Manho; Roh, Jae-Kyu
Issue Date
2004-04-15
Publisher
Elsevier
Citation
Brain Res. 2005 Apr 18;1041(2):125-31.
Keywords
AnimalsAtrophy/drug therapy/etiology/physiopathologyBiological Markers/metabolismBlood-Brain Barrier/drug effects/physiopathologyBrain Edema/drug therapy/etiology/physiopathologyCerebral Hemorrhage/complications/*drug therapy/physiopathologyCollagenasesDisease Models, AnimalEncephalitis/drug therapy/etiology/physiopathologyEvans Blue/diagnostic useGranulocyte Colony-Stimulating Factor/*therapeutic useMaleMotor Activity/drug effects/physiologyMovement Disorders/*drug therapy/etiology/physiopathologyNerve Degeneration/drug therapy/etiology/physiopathologyNeuroprotective Agents/pharmacology/therapeutic useRatsRats, Sprague-DawleyRecovery of Function/*drug effects/physiologySensation Disorders/*drug therapy/etiology/physiopathologyTreatment Outcome
Abstract
Granulocyte colony-stimulating factor (G-CSF) has been used in the treatment of neutropenia in hematologic disorders. The neuroprotective and anti-inflammatory effects of G-CSF were reported in various neurological disease models. In this study, we examined whether G-CSF induces functional recovery after intracerebral hemorrhage (ICH). ICH was induced using collagenase injection in adult rats. Either G-CSF (50 microg/kg, i.p.) or saline was given from 2 h after ICH and every 24 h for 3 days. 72 h after ICH induction, the rats were sacrificed for histological analysis and measurement of brain edema. Behavioral tests were performed before and 1, 7, 14, 21, 28, and 35 days after ICH. We also measured the blood-brain barrier (BBB) permeability using Evans blue dye injection method. G-CSF-treated rats recovered better on rotarod and limb placing tests, starting from 14 days throughout 5 weeks after ICH. The brain water content and BBB permeability of G-CSF-treated group decreased in the lesioned hemispheres compared with those of ICH-only group. In G-CSF-treated group, the number of TUNEL+, myeloperoxidase+, and OX42+ cells was smaller than that of ICH-only group in the periphery of hematoma. These findings suggest that G-CSF induces long-term sensorimotor recovery after ICH with reduction of brain edema, inflammation, and perihematomal cell death.
ISSN
0006-8993 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15829221

http://hdl.handle.net/10371/15289
DOI
https://doi.org/10.1016/j.brainres.2004.11.067
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Neurology (신경과학교실)Journal Papers (저널논문_신경과학교실)
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