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Preparation of Polymeric Nanoparticles using Poly(D,L-lactide) grafted Poly(ethylene glycol)-b-Poly(L-seirne) Block Copolymers
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 장지영 | - |
dc.contributor.author | 박준범 | - |
dc.date.accessioned | 2019-06-25T16:24:15Z | - |
dc.date.available | 2019-06-25T16:24:15Z | - |
dc.date.issued | 2012-02 | - |
dc.identifier.other | 000000000257 | - |
dc.identifier.uri | https://hdl.handle.net/10371/155437 | - |
dc.identifier.uri | http://dcollection.snu.ac.kr/jsp/common/DcLoOrgPer.jsp?sItemId=000000000257 | - |
dc.description | 학위논문 (석사)-- 서울대학교 대학원 : 재료공학부, 2012. 2. 장지영. | - |
dc.description.abstract | Core-shell structured nanoparticles of poly(ethylene glycol)-b-[poly(Lserine)-g-poly(D,L-lactide)] (PEG-PSER-PLA) copolymer were prepared. The copolymer had a poly(L-serine) (PSER) block as a linker between a hydrophilic poly(ethylene glycol) (PEG) and a hydrophobic poly(D,L-lactide) (PLA) unit. It formed core-shell structured nanoparticles, where the polypeptide block resided at the interface between a hydrophilic PEG shell and a hydrophobic PLA core. In the synthesis, poly(ethylene glycol)-b-poly(L-serine) (PEG-PSER) was prepared by ring opening polymerization of N-carboxyanhydride of O-(tertbutyl)-L-serine and subsequent removal of tert-butyl groups. Methoxypoly( ethylene glycol)-amine with a MW of 5000 was used as an initiator for the polymerization. The polymerization of D,L-lactide by initiation with PEG-PSER produced a comb-like copolymer, PEG-PSER-PLA. The nanoparticles obtained from PEG-PSER-PLA copolymer had a diameter of ~200 nm and showed a positive zeta potential value of 19.3 mV. The release profile of the nanoparticles prepared from PEG-PSER-PLA was investigated by using 1-
aminopyrene. In pH 3.0 phosphate buffer solution at 36 ℃, 1-aminopyrene was more slowly released from the nanoparticles of PEG-PSER-PLA copolymer than those of a linear PEG-PLA copolymer. The nanoparticles of PEG-PSERPLA copolymer showed much better stability than those of a linear PEG-PLA copolymer having a comparable molecular weight in an aqueous solution. | - |
dc.format.extent | 43 | - |
dc.language.iso | eng | - |
dc.publisher | 서울대학교 대학원 | - |
dc.subject.ddc | 620.1 | - |
dc.title | Preparation of Polymeric Nanoparticles using Poly(D,L-lactide) grafted Poly(ethylene glycol)-b-Poly(L-seirne) Block Copolymers | - |
dc.type | Thesis | - |
dc.type | Dissertation | - |
dc.description.degree | Master | - |
dc.contributor.affiliation | 재료공학부 | - |
dc.date.awarded | 2012-02 | - |
dc.identifier.holdings | 000000000006▲000000000011▲000000000257▲ | - |
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