synthesis of chiral 2,3-diamino acid derivatives using diaza-cope rearrangement

Abstract

Chiral vicinal diamine derivatives are important starting materials not only for stereoselctive catalysts, but also for diverse durgs. Because of this reasons, many interesting chiral vicinal diamine derivatives have been synthesized by oxidation, reduction, reductive coupling, C-C bond forming reactions and chiral resolutions. We developed a stereospecific synthesis of chiral vicinal α-β-diamino ester Using diaza-Cope rearrangement reaction.