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Quality of life outcomes including neuropathy-associated scale from a phase II, multicenter, randomized trial of eribulin plus gemcitabine versus paclitaxel plus gemcitabine as first-line chemotherapy for HER2-negative metastatic breast cancer: Korean Cancer Study Group Trial (KCSG BR13-11)

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Authors
Kim, Ji-Yeon; Park, Seri; Im, Seock-Ah; Kim, Sung-Bae; Sohn, Joohyuk; Lee, Keun Seok; Chae, Yee Soo; Lee, Ki Hyeong; Kim, Jee Hyun; Im, Young-Hyuck; Kim, Tae-Yong; Lee, Kyung-Hun; Ahn, Jin-Hee; Kim, Gun Min; Park, In Hae; Lee, Soo Jung; Han, Hye Sook; Kim, Se Hyun; Jung, Kyung Hae; Park, Yeon Hee
Issue Date
2019-05-28
Publisher
BioMed Central
Citation
Cancer Communications. 39(1):29
Abstract
Background
A phase II clinical trial of the comparison between eribulin plus gemcitabine (EG) and paclitaxel plus gemcitabine (PG) as first-line chemotherapy for patients with metastatic breast cancer (MBC) found that the EG regimen was less neurotoxic, but was similar in efficacy to the PG regimen. In the present study, we analyzed functional assessment of cancer therapy-taxane (FACT-Taxane) questionnaires from patients in this clinical trial to determine their quality of life (QoL).

Methods
QoL was assessed using the Korean version of the FACT-Taxane questionnaires. After baseline assessment, QoL was assessed every 2 cycles for 12 cycles and every 3 cycles thereafter. The linear mixed model was used to evaluate the difference in QoL between the EG and PG arms.

Results
Of the 118 enrolled patients, 117 responded to the FACT-Taxane questionnaires at baseline, 1 in the PG arm did not. Baseline QoL scores were not different between the EG and PG arms. During treatment, taxane subscale scores were significantly higher in the PG arm than in the EG arm after 2–13 cycles of chemotherapy (all P < 0.05), except for the 11th cycle. Neuropathy-specific analysis showed that patients in the PG arm had earlier and more severe neuropathic symptoms than those in the EG arm (P < 0.001).

Conclusions
In our QoL analysis, the EG regimen delayed and decreased neuropathy as compared with the PG regimen. Therefore, eribulin would be a reasonable substitute for paclitaxel as first-line chemotherapy for MBC.
ISSN
2523-3548
Language
English
URI
http://hdl.handle.net/10371/156045
DOI
https://doi.org/10.1186/s40880-019-0375-7
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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