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The clinical significance of early histological rejection with or without biochemical abnormality in adult living donor liver transplantation for hepatitis B virus related end stage liver disease
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cho, Jai Young | - |
dc.contributor.author | Suh, Kyung-Suk | - |
dc.contributor.author | Lee, Hae Won | - |
dc.contributor.author | Cho, Eung-Ho | - |
dc.contributor.author | Yang, Sung Hoon | - |
dc.contributor.author | Cho, Yong Beom | - |
dc.contributor.author | Yi, Nam-Joon | - |
dc.contributor.author | Kim, Min A | - |
dc.contributor.author | Jang, Ja-June | - |
dc.contributor.author | Lee, Kuhn Uk | - |
dc.date.accessioned | 2009-11-26T02:01:06Z | - |
dc.date.available | 2009-11-26T02:01:06Z | - |
dc.date.issued | 2006-12-22 | - |
dc.identifier.citation | Transpl Int. 2007 Jan;20(1):37-44. | en |
dc.identifier.issn | 0934-0874 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17181651 | - |
dc.identifier.uri | https://hdl.handle.net/10371/15605 | - |
dc.description.abstract | There is no agreement regarding the treatment of early allograft rejection (EAR) in adult living donor liver transplantation (LDLT). A protocol biopsy was performed in 62 adult LDLT recipients. Twenty-one patients (33.9%) had histological evidence of EAR. Of these, 14 patients had biochemical abnormalities and seven patients had no associated biochemical abnormalities. None of the seven patients with subclinical EAR (11.3% of the entire study population) were treated, and no subsequent rejection was observed. Gender mismatch (female-to-male) was the single independent risk factor for histological EAR [odds ratio (OR) = 13.458; 95% confidence interval (CI), 1.836-98.649] and the cumulative probability for a subsequent rejection was higher in patients with EAR (OR = 11.085; 95% CI, 1.221-100.654). However, the actuarial 1 year patient and graft survival rate in patients with EAR (81.0% and 85.5%) were similar to those without EAR (92.7% and 97.25%; P = 0.127 and 0.302, respectively). The presence of an initial biochemical abnormality was an independent risk factor for both a decreased patient survival (OR = 5.827; 95% CI, 1.095-31.017; P = 0.039) and graft loss (OR = 20.646; 95% CI, 2.044-208.524; P = 0.010). Subsequent rejection developed more frequently in patients with EAR. However, the survival is not determined by the presence of EAR but by the presence of a biochemical abnormality. | en |
dc.language.iso | en | - |
dc.publisher | Blackwell Publishing | en |
dc.subject | Adult | en |
dc.subject | Biopsy | en |
dc.subject | Female | en |
dc.subject | Graft Rejection/immunology/*pathology | en |
dc.subject | Graft Survival | en |
dc.subject | Hepatitis B/*complications/pathology | en |
dc.subject | Humans | en |
dc.subject | Immunosuppressive Agents/therapeutic use | en |
dc.subject | Liver Failure, Acute/immunology/pathology/*surgery/virology | en |
dc.subject | Liver Transplantation/immunology/mortality/*pathology | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Survival Analysis | en |
dc.subject | Living Donors | - |
dc.title | The clinical significance of early histological rejection with or without biochemical abnormality in adult living donor liver transplantation for hepatitis B virus related end stage liver disease | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 조재영 | - |
dc.contributor.AlternativeAuthor | 서경석 | - |
dc.contributor.AlternativeAuthor | 이해원 | - |
dc.contributor.AlternativeAuthor | 조응호 | - |
dc.contributor.AlternativeAuthor | 양성훈 | - |
dc.contributor.AlternativeAuthor | 조용범 | - |
dc.contributor.AlternativeAuthor | 이남준 | - |
dc.contributor.AlternativeAuthor | 김민아 | - |
dc.contributor.AlternativeAuthor | 장자준 | - |
dc.contributor.AlternativeAuthor | 이건욱 | - |
dc.identifier.doi | 10.1111/j.1432-2277.2006.00384.x | - |
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