S-Space College of Medicine/School of Medicine (의과대학/대학원) Obstetrics & Gynecology (산부인과전공) Journal Papers (저널논문_산부인과학전공)
Epstein-Barr virus plays little role in cervical carcinogenesis in Korean women
- Seo, S S; Kim, W H; Song, Y S; Kim, S H; Kim, J W; Park, N H; Kang, S B; Lee, H P
- Issue Date
- Int J Gynecol Cancer. 2005 Mar-Apr;15(2):312-8.
- Adenocarcinoma/ethnology/*etiology/*virology; Carcinoma, Small Cell/ethnology/*etiology/*virology; *Cell Transformation, Neoplastic; DNA Primers; DNA, Viral; Epstein-Barr Virus Infections/*complications; Female; Herpesvirus 4, Human/genetics/*pathogenicity; Humans; In Situ Hybridization; Korea/ethnology; Polymerase Chain Reaction; Uterine Cervical Neoplasms/ethnology/*etiology/*virology
- We examined whether Epstein-Barr virus (EBV) infection plays a role in cervical carcinogenesis in Korean women. EBV infection was examined using polymerase chain reaction (PCR) with two different primer pairs flanking the BamHI "W" fragment of EBV and by EBV-encoded small RNAs (EBER) in situ hybridization in various histologic types of cervical cancer, including 17 cases of squamous cell carcinoma, 36 cases of adenocarcinoma, and 3 cases of small-cell carcinoma. We also evaluated 20 cases of cervical intraepithelial neoplasia and 20 cases of normal uterine cervix. One case of squamous cell carcinoma and three cases of cervical intraepithelial neoplasia were positive for EBV DNA using PCR, but EBER in situ hybridization analysis showed that none of the PCR-positive cases expressed EBER. EBV DNA was not found using PCR in any of the 20 normal uterine cervices. From our results, EBV infection does not seem to play a role in cervical carcinogenesis in Korean women.
- 1048-891X (Print)
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