Publications
Detailed Information
Genetic polymorphisms of NOS3 are associated with the risk of invasive breast cancer with lymph node involvement
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Kyoung-Mu | - |
dc.contributor.author | Choi, Ji-Yeob | - |
dc.contributor.author | Lee, Jong Eun | - |
dc.contributor.author | Noh, Dong-Young | - |
dc.contributor.author | Ahn, Sei-Hyun | - |
dc.contributor.author | Han, Wonshik | - |
dc.contributor.author | Yoo, Keun-Young | - |
dc.contributor.author | Hayes, Richard B | - |
dc.contributor.author | Kang, Daehee | - |
dc.date.accessioned | 2009-11-26T02:12:08Z | - |
dc.date.available | 2009-11-26T02:12:08Z | - |
dc.date.issued | 2007-01-31 | - |
dc.identifier.citation | Breast Cancer Res Treat. 2007 Dec;106(3):433-8. Epub 2007 Jan 30 | en |
dc.identifier.issn | 0167-6806 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17262178 | - |
dc.identifier.uri | https://hdl.handle.net/10371/15618 | - |
dc.description.abstract | Endothelial nitric oxide synthase (NOS3) produces nitric oxide which is a mediator of cytotoxic effects potentially associated with breast cancer. We evaluated the role of genetic polymorphisms of NOS3 in breast cancer etiology, in a case-control study conducted in Korea. We recruited 1,385 eligible patients with histologically confirmed incident breast cancer cases and 968 hospital-based controls. Two potentially functional NOS3 polymorphisms in the promoter region (-786T > C) and exon 7 (894G > T, Glu298Asp) were genotyped and individual haplotypes were estimated. Odds ratios (ORs) and 95% confidential intervals (95% CIs) were calculated by unconditional logistic regression, adjusting for age, body mass index, education, family history of breast cancer in first and second degree relatives, age at first full-term pregnancy and parity. There was no overall association between the -786T > C or 894G > T genotype and breast cancer risk. However, the -786C allele was marginally associated with decreased risk for invasive breast cancer with lymph node involvement (OR = 0.76, 95% CI = 0.56-1.04). And, compared to TG-TG carriers, all other haplotype pairs were significantly associated with invasive breast cancer with lymph node involvement (OR = 0.77, 95% CI = 0.59-0.99). Our results suggest that genetic polymorphisms in NOS3 modify individual susceptibility to invasive breast cancer with lymph node involvement in Korean women. | en |
dc.language.iso | en | en |
dc.publisher | Springer Verlag | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Breast Neoplasms/*genetics/pathology | en |
dc.subject | Case-Control Studies | en |
dc.subject | Female | en |
dc.subject | Genetic Predisposition to Disease | en |
dc.subject | Humans | en |
dc.subject | Lymphatic Metastasis | en |
dc.subject | Middle Aged | en |
dc.subject | Nitric Oxide Synthase Type III/*genetics | en |
dc.subject | Risk | en |
dc.subject | Polymorphism, Genetic | - |
dc.title | Genetic polymorphisms of NOS3 are associated with the risk of invasive breast cancer with lymph node involvement | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 이경무 | - |
dc.contributor.AlternativeAuthor | 최지엽 | - |
dc.contributor.AlternativeAuthor | 이종은 | - |
dc.contributor.AlternativeAuthor | 노동영 | - |
dc.contributor.AlternativeAuthor | 안세현 | - |
dc.contributor.AlternativeAuthor | 한원식 | - |
dc.contributor.AlternativeAuthor | 유근영 | - |
dc.contributor.AlternativeAuthor | 강대희 | - |
dc.identifier.doi | 10.1007/s10549-007-9506-y | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.