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Normal pregnancy is characterized by systemic activation of the complement system
DC Field | Value | Language |
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dc.contributor.author | Richani, Karina | - |
dc.contributor.author | Soto, Eleazar | - |
dc.contributor.author | Romero, Roberto | - |
dc.contributor.author | Espinoza, Jimmy | - |
dc.contributor.author | Chaiworapongsa, Tinnakorn | - |
dc.contributor.author | Nien, Jyh Kae | - |
dc.contributor.author | Edwin, Samuel | - |
dc.contributor.author | Kim, Yeon Mee | - |
dc.contributor.author | Hong, Joon-Seok | - |
dc.contributor.author | Mazor, Moshe | - |
dc.date.accessioned | 2009-11-26T02:16:18Z | - |
dc.date.available | 2009-11-26T02:16:18Z | - |
dc.date.issued | 2005-09-09 | - |
dc.identifier.citation | J Matern Fetal Neonatal Med. 2005 Apr;17(4):239-45. | en |
dc.identifier.issn | 1476-7058 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16147832 | - |
dc.identifier.uri | https://hdl.handle.net/10371/15625 | - |
dc.description.abstract | BACKGROUND: The complement system, a major component of innate immunity, has recently been implicated in the mechanisms of fetal loss and placental inflammation in the anti-phospholipid antibody syndrome. Inhibition of complement has been proposed as an absolute requirement for normal pregnancy. Yet, pregnancy is characterized by a generalized activation of the innate immune system. This study was conducted to determine whether or not normal pregnancy is associated with complement activation in the maternal circulation. METHODS: Anaphylatoxins (C3a, C4a and C5a) were determined in the plasma of normal pregnant (20-42 wks; n=134) and non-pregnant women (n=40). These complement split products (C3a, C4a and C5a) were measured using specific immunoassays. Non-parametric statistics were used for analysis. RESULTS: 1) The median plasma concentrations of C3a, C4a and C5a were significantly higher in normal pregnant women than in non-pregnant women (all p<0.001); 2) the concentration of C3a, C4a and C5a did not change with gestational age (p>0.05); and 3) the median plasma concentration of C3a had a positive correlation with the plasma C4a and C5a concentrations (r=0.36, p<0.001 and r=0.35, p<0.001, respectively). CONCLUSION: 1) Normal human pregnancy is associated with evidence of complement activation, as determined by higher concentrations of the anaphylatoxins C3a, C4a and C5a in the maternal circulation; and 2) we propose that physiologic activation of the complement system during pregnancy is a compensatory mechanism aimed at protecting the host against infection. | en |
dc.language.iso | en | en |
dc.publisher | Taylor & Francis | en |
dc.subject | Adolescent | en |
dc.subject | Adult | en |
dc.subject | Anaphylatoxins/analysis/*immunology | en |
dc.subject | Complement System Proteins/*immunology | en |
dc.subject | Cross-Sectional Studies | en |
dc.subject | Female | en |
dc.subject | Humans | en |
dc.subject | Immunity, Innate/immunology | en |
dc.subject | Pregnancy/blood/*immunology | en |
dc.title | Normal pregnancy is characterized by systemic activation of the complement system | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김연미 | - |
dc.contributor.AlternativeAuthor | 홍준석 | - |
dc.identifier.doi | 10.1080/14767050500072722 | - |
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