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Maternal serum concentrations of the chemokine CXCL10/IP-10 are elevated in acute pyelonephritis during pregnancy
DC Field | Value | Language |
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dc.contributor.author | Gotsch, Francesca | - |
dc.contributor.author | Romero, Roberto | - |
dc.contributor.author | Espinoza, Jimmy | - |
dc.contributor.author | Kusanovic, Juan Pedro | - |
dc.contributor.author | Mazaki-Tovi, Shali | - |
dc.contributor.author | Erez, Offer | - |
dc.contributor.author | Than, Nandor Gabor | - |
dc.contributor.author | Edwin, Samuel | - |
dc.contributor.author | Mazor, Moshe | - |
dc.contributor.author | Yoon, Bo Hyan | - |
dc.contributor.author | Hassan, Sonia S | - |
dc.date.accessioned | 2009-11-26T02:26:41Z | - |
dc.date.available | 2009-11-26T02:26:41Z | - |
dc.date.issued | 2007-09-01 | - |
dc.identifier.citation | J Matern Fetal Neonatal Med. 2007 Oct;20(10):735-44. | en |
dc.identifier.issn | 1476-7058 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17763275 | - |
dc.identifier.uri | https://hdl.handle.net/10371/15632 | - |
dc.description.abstract | OBJECTIVE: Acute pyelonephritis is one of the most frequent medical complications of pregnancy, as well as a common cause of antepartum hospitalization. Interferon (IFN)-gamma inducible protein, CXCL10/IP-10, is a member of the CXC chemokine family with pro-inflammatory and anti-angiogenic properties. The purpose of this study was to determine whether maternal serum concentrations of CXCL10/IP-10 change in patients with acute pyelonephritis during pregnancy. STUDY DESIGN: This cross-sectional study was conducted to determine the difference in maternal serum concentrations of CXCL10/IP-10 in pregnant women with acute pyelonephritis (N = 41) and normal pregnant women (N = 89). Pyelonephritis was defined in the presence of a positive urine culture, fever, and maternal clinical signs; blood cultures were performed in 36 cases. Maternal serum concentrations of CXCL10/IP-10 were measured by a sensitive immunoassay. Non-parametric statistics were used for analysis. RESULTS: (1) The median serum concentration of CXCL10/IP-10 in pregnant patients with pyelonephritis was significantly higher than in normal pregnant women (median 318.5 pg/mL, range 78.8-2459.2 vs. median 116.1 pg/mL, range 40.7-1314.3, respectively; p < 0.001); (2) maternal median serum concentrations of CXCL10/IP-10 did not differ significantly among patients with acute pyelonephritis with and without bacteremia (positive blood cultures: median 362.6 pg/mL, range 100.2-2459.2 vs. negative blood cultures: median 298.9 pg/mL, range 108.5-1148.7, respectively; p = 0.3). CONCLUSIONS: Pyelonephritis in pregnant women is associated with an increased maternal serum concentration of the chemokine CXCL10/IP-10. | en |
dc.language.iso | en | - |
dc.publisher | Taylor & Francis | en |
dc.subject | Bacteremia/blood | en |
dc.subject | Bacteriuria/complications | en |
dc.subject | Biological Markers | en |
dc.subject | Case-Control Studies | en |
dc.subject | Chemokine CXCL10/*blood | en |
dc.subject | Cross-Sectional Studies | en |
dc.subject | Female | en |
dc.subject | Humans | en |
dc.subject | Pregnancy | en |
dc.subject | Pregnancy Complications, Infectious/*blood/immunology | en |
dc.subject | Pyelonephritis/*blood/complications/immunology | en |
dc.title | Maternal serum concentrations of the chemokine CXCL10/IP-10 are elevated in acute pyelonephritis during pregnancy | en |
dc.type | Article | en |
dc.identifier.doi | 10.1080/14767050701511650 | - |
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