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Chromosomal constitution of embryos derived from tripronuclear zygotes studied by fluorescence in situ hybridization using probes for chromosomes 4, 13, 18, 21, X, and Y
DC Field | Value | Language |
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dc.contributor.author | Pang, Myung-Geol | - |
dc.contributor.author | Jee, Byung-Chul | - |
dc.contributor.author | Kim, Seok-Hyun | - |
dc.contributor.author | Ryu, Buom-Yong | - |
dc.contributor.author | Oh, Sun-Kyung | - |
dc.contributor.author | Suh, Chang-Suk | - |
dc.contributor.author | Moon, Shin-Yong | - |
dc.date.accessioned | 2009-11-26T02:28:54Z | - |
dc.date.available | 2009-11-26T02:28:54Z | - |
dc.date.issued | 2005-01-04 | - |
dc.identifier.citation | Gynecol Obstet Invest. 2005;59(1):14-8. Epub 2004 Aug 18. | en |
dc.identifier.issn | 0378-7346 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15627776 | - |
dc.identifier.uri | https://hdl.handle.net/10371/15635 | - |
dc.description.abstract | This study was designed to assess the chromosomal constitution and segregation patterns of cleaving embryos derived from tripronuclear zygotes. Thirty-two embryos obtained from 19 conventional IVF patients were analyzed by fluorescence in situ hybridization (FISH) using probes for chromosomes 4, 13, 18, 21, X, and Y. Sixteen embryos (50.0%) exhibited uniform, non-mosaic patterns. These embryos showed pure triploid (n = 7), pure diploid (n = 7), or pure haploid (n = 2). The remaining 16 embryos showed mosaic patterns; 1 was triploid-diploid mosaics, 9 were diploid-haploid, and 4 were haploid only. Autosomal aneuploidy occurred in 2 embryos showing a triploid complement. The sex chromosomal constituent XXX:XXY:XYY was 3:4:2 in embryos showing a pure triploid complement (including 2 embryos with aneuploidy). This ratio was not significantly different from the expected 1:2:1 (p = 0.96). Pure triploid was found in 41.7% of 2-cell embryos, but no triploid complement was found in 3-cell embryos. The present study also supports the diandric origin of tripronuclear zygotes in the conventional IVF, and, to our knowledge, is the first study to use simultaneous six-color FISH for chromosomes 4, 13, 18, 21, X, and Y in human embryos. However, no additive information was obtained about chromosome 4. | en |
dc.language.iso | en | en |
dc.publisher | Karger | en |
dc.subject | Embryo, Mammalian/*physiology | en |
dc.subject | Fertilization in Vitro | en |
dc.subject | Humans | en |
dc.subject | In Situ Hybridization, Fluorescence/*methods | en |
dc.subject | Zygote | en |
dc.subject | Chromosome Aberrations | - |
dc.subject | Chromosomes, Human | - |
dc.subject | Sex Chromosomes | - |
dc.title | Chromosomal constitution of embryos derived from tripronuclear zygotes studied by fluorescence in situ hybridization using probes for chromosomes 4, 13, 18, 21, X, and Y | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 방명걸 | - |
dc.contributor.AlternativeAuthor | 지병철 | - |
dc.contributor.AlternativeAuthor | 김석현 | - |
dc.contributor.AlternativeAuthor | 류범용 | - |
dc.contributor.AlternativeAuthor | 오선경 | - |
dc.contributor.AlternativeAuthor | 서창석 | - |
dc.contributor.AlternativeAuthor | 문신용 | - |
dc.identifier.doi | 10.1159/000080522 | - |
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