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Exercise increased BDNF and trkB in the contralateral hemisphere of the ischemic rat brain

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Authors
Kim, Min-Wook; Bang, Moon-Sug; Han, Tae-Ryoon; Ko, Young-Jin; Yoon, Byung-Woo; Kim, Jong-Hyun; Kang, La-Mi; Lee, Kyoung-Mi; Kim, Man-Ho
Issue Date
2005-08-02
Publisher
Elsevier
Citation
Brain Res. 2005 Aug 2;1052(1):16-21
Keywords
AnimalsBlotting, Western/methodsBrain/metabolismBrain Ischemia/etiology/metabolism/*rehabilitationBrain-Derived Neurotrophic Factor/*metabolismDisease Models, AnimalExercise Test/methodsFunctional Laterality/*physiologyGene Expression Regulation/*physiologyImmunohistochemistry/methodsInfarction, Middle Cerebral Artery/complicationsMaleMotor Activity/physiologyPhysical Conditioning, Animal/*physiologyRatsRats, Sprague-DawleyReceptor, trkB/*metabolismTime Factors
Abstract
Previous studies have suggested that brain-derived neurotrophic factor (BDNF) and trkB both have a role in plasticity following brain insults and exercise increases BDNF and trkB mRNA levels in the normal brain. We attempted to determine whether treadmill exercise improves motor function following experimental cerebral ischemia, and whether motor outcome is associated with BDNF and trkB expression. We subjected adult male Sprague-Dawley rats to a permanent ischemia, followed by either 12 days of treadmill exercise or non-exercise. In the exercise group, improvements in the motor behavior index were found and BDNF and trkB proteins in contralateral hemisphere were increased. This study suggests that after permanent brain ischemia, exercise improves motor performance and elevates BDNF and trkB proteins in the contralateral hemisphere.
ISSN
0006-8993 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16054599

http://hdl.handle.net/10371/15671
DOI
https://doi.org/10.1016/j.brainres.2005.05.070
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College of Medicine/School of Medicine (의과대학/대학원)Rehabilitation Medicine (재활의학전공)Journal Papers (저널논문_재활의학전공)
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