A comparison of two cyclosporine dosage regimens for the treatment of severe psoriasis

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Yoon, Hyun Sun; Youn, Jai Il
Issue Date
Taylor & Francis
J Dermatolog Treat. 2007;18(5):286-90.
AdultAgedCyclosporine/*administration & dosage/adverse effectsDrug Administration ScheduleDrug Dosage CalculationsFemaleHumansImmunosuppressive Agents/*administration & dosage/adverse effectsMaleMiddle AgedPsoriasis/*drug therapy/pathologySeverity of Illness IndexSkin/pathologyTreatment Outcome
BACKGROUND: Few reports have been issued which compare the efficacy and tolerability of cyclosporine dose adjustments before 12 weeks of treatment. OBJECTIVE: To compare the efficacy and tolerability of two different dosage regimens of cyclosporine in severe psoriasis. METHODS: This 12-week, prospective, open-label study included 61 severe psoriasis patients. Patients were assigned to a 2.5 mg/kg per day starting dose and an increasing regimen ('standard regimen') or a 5.0 mg/kg per day starting dose and a decreasing regimen ('step-down regimen') group. The end point included 50% and 75% reductions in Psoriasis Area and Severity Index (PASI) scores. Adverse events were also evaluated. RESULTS: According to a 50% PASI reduction (PASI 50), the response rate at 12 weeks was similar for two groups. The percentage of patients achieving a 75% PASI reduction (PASI 75) at 12 weeks was higher in the step-down regimen group. The mean time to PASI 50 or PASI 75 was shorter in the step-down regimen group. No difference was found between the two groups in terms of the number of patients with adverse events requiring intervention. CONCLUSION: This study suggests that the 'step-down' cyclosporine regimen offers an effective and safe therapeutic option for the management of severe psoriasis.
0954-6634 (Print)
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College of Medicine/School of Medicine (의과대학/대학원)Dermatology (피부과학전공)Journal Papers (저널논문_피부과학전공)
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