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Plasma protein Z concentrations in pregnant women with idiopathic intrauterine bleeding and in women with spontaneous preterm labor
DC Field | Value | Language |
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dc.contributor.author | Kusanovic, Juan Pedro | - |
dc.contributor.author | Espinoza, Jimmy | - |
dc.contributor.author | Romero, Roberto | - |
dc.contributor.author | Hoppensteadt, Debra | - |
dc.contributor.author | Nien, Jyh Kae | - |
dc.contributor.author | Kim, Chong Jai | - |
dc.contributor.author | Erez, Offer | - |
dc.contributor.author | Soto, Eleazar | - |
dc.contributor.author | Fareed, Jawed | - |
dc.contributor.author | Edwin, Sam | - |
dc.contributor.author | Chaiwerapongsa, Tinnakorn | - |
dc.contributor.author | Than, Nador G | - |
dc.contributor.author | Yoon, Bo Hyun | - |
dc.contributor.author | Gomez, Ricardo | - |
dc.contributor.author | Papp, Zoltan | - |
dc.contributor.author | Hassan, Sonia S | - |
dc.date.accessioned | 2009-11-26T03:09:41Z | - |
dc.date.available | 2009-11-26T03:09:41Z | - |
dc.date.issued | 2007-08-04 | - |
dc.identifier.citation | J Matern Fetal Neonatal Med. 2007 Jun;20(6):453-63. | en |
dc.identifier.issn | 1476-7058 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17674255 | - |
dc.identifier.uri | https://hdl.handle.net/10371/15740 | - |
dc.description.abstract | OBJECTIVES: Preterm parturition has been associated with decidual vascular disorders and excessive thrombin generation. The objective of this study was to examine maternal plasma concentrations of protein Z in normal pregnancies, as well as in those presenting with spontaneous preterm labor (PTL) and intrauterine bleeding during pregnancy. STUDY DESIGN: A cross-sectional study was designed to include patients with preterm labor and intact membranes and those with idiopathic intrauterine bleeding during pregnancy. Protein Z plasma concentrations were measured in the following groups: (1) normal pregnant women (n = 71); (2) patients at term with (n = 67) and without labor (n = 88); (3) patients with spontaneous PTL before 34 weeks who were classified into: (a) PTL with intra-amniotic infection/inflammation (IAI; n = 35), (b) PTL without IAI (n = 54), and (c) patients with PTL who delivered at term (n = 49); and (4) patients with idiopathic intrauterine bleeding in the second and third trimester who were divided into: (a) subsequent spontaneous PTL and delivery, and (b) term delivery. Maternal plasma protein Z concentration was measured by a specific and sensitive immunoassay. Moreover, the amniotic fluid concentration of protein Z was determined in a subset of patients with preterm labor (n = 30). RESULTS: (1) There was no correlation between maternal plasma protein Z concentration and gestational age in normal pregnant women. (2) The mean maternal plasma concentration of protein Z was significantly lower in women during spontaneous labor at term than in those not in labor (mean 2.15 microg/mL (95% CI 2.01-2.29) vs. mean 2.45+/-0.52 microg/mL (95% CI 2.34-2.56), respectively; p = 0.001). (3) Women with PTL without IAI who delivered preterm had a significantly lower mean protein Z concentration than normal pregnant women (mean 2.12 mug/mL (95% CI 1.98-2.26) vs. mean 2.39 microg/mL (95% CI 2.28-2.5); p = 0.008). (4) Of interest, PTL with IAI was not associated with lower plasma concentrations of protein Z, nor were those with PTL who delivered at term (p > 0.05 for each). (5) No differences were found in the maternal plasma concentrations of anti-protein Z antibodies between normal pregnancies and those with spontaneous PTL. (6) Patients with idiopathic intrauterine bleeding who had spontaneous PTL and delivery had a significantly lower mean plasma protein Z concentration than those who delivered at term (mean 1.24 microg/mL (95% CI 1.08-1.4) vs. mean 1.49+/-0.47 microg/mL (95% CI 1.33-1.65), respectively; p = 0.03). (7) Amniotic fluid was found to contain immunoreactive protein Z. CONCLUSIONS: (1) Patients with PTL leading to preterm delivery in the absence of IAI had a significantly lower plasma concentration of protein Z than those with normal pregnancies. (2) Patients with idiopathic intrauterine bleeding and subsequently spontaneous PTL and delivery had a significantly lower plasma concentration of protein Z than those with idiopathic intrauterine bleeding who delivered at term. (3) Protein Z was present in the amniotic fluid of patients with PTL. Collectively, these observations suggest that a subgroup of patients with PTL have a hemostatic disorder that involves bleeding/thrombosis as a mechanism of disease. | en |
dc.language.iso | en | - |
dc.publisher | Taylor & Francis | en |
dc.subject | Adolescent | en |
dc.subject | Adult | en |
dc.subject | Amniotic Fluid/chemistry | en |
dc.subject | Blood Proteins/*analysis/immunology | en |
dc.subject | Cross-Sectional Studies | en |
dc.subject | Female | en |
dc.subject | Humans | en |
dc.subject | Immunoglobulin G/blood | en |
dc.subject | Immunoglobulin M/blood | en |
dc.subject | Obstetric Labor, Premature/*blood | en |
dc.subject | Pregnancy | en |
dc.subject | Uterine Hemorrhage/*blood | en |
dc.title | Plasma protein Z concentrations in pregnant women with idiopathic intrauterine bleeding and in women with spontaneous preterm labor | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김종재 | - |
dc.contributor.AlternativeAuthor | 윤보현 | - |
dc.identifier.doi | 10.1080/14767050701398272 | - |
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