Publications
Detailed Information
Modulation of E-cadherin by hepatocyte growth factor induces aggressiveness of gastric carcinoma
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Han, Sang-Uk | - |
dc.contributor.author | Lee, Hwa-Young | - |
dc.contributor.author | Lee, Jae-Ho | - |
dc.contributor.author | Kim, Wook-Hwan | - |
dc.contributor.author | Nam, Hyunja | - |
dc.contributor.author | Kim, Hong | - |
dc.contributor.author | Cho, Yong-Kwan | - |
dc.contributor.author | Kim, Myung-Wook | - |
dc.contributor.author | Lee, Kuhn Uk | - |
dc.date.accessioned | 2009-11-26T05:21:31Z | - |
dc.date.available | 2009-11-26T05:21:31Z | - |
dc.date.issued | 2005-10-26 | - |
dc.identifier.citation | Ann Surg. 2005 Nov;242(5):676-83 | en |
dc.identifier.issn | 0003-4932 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16244541 | - |
dc.identifier.uri | https://hdl.handle.net/10371/15922 | - |
dc.description.abstract | OBJECTIVE: Hepatocyte growth factor (HGF) is well known as a scatter factor because it can disperse cells. E-cadherin is a protein that plays a main role in the establishment of cell-cell adhesion. This study focused on the role of HGF on the expression and distribution of E-cadherin. Furthermore, we found induction of aggressiveness of gastric carcinoma by modulation of E-cadherin by HGF. MATERIALS AND METHODS: Tumor tissues from 50 patients with gastric carcinoma were evaluated for the expression of HGF, its receptor c-Met, and E-cadherin. Western blot analysis and invasion assay were performed to confirm the role of HGF on the modulation of E-cadherin using human gastric cancer cell lines. RESULTS: Seventy-eight percent of the gastric carcinoma tissues showed overexpression of c-Met. E-cadherin expression was found in 86%, which could be further classified as membranous type (52%) or nonmembranous type (48%). The levels of HGF in tumor tissues increased significantly according to the tumor progression. The levels of HGF in tumors with nonmembranous type E-cadherin expression were significantly higher than those in tumors with membranous expression. A striking morphologic change from epithelial shape to fibroblastic shape was observed in SNU-16 cells after 3 days' exposure to HGF, accompanied by down-regulation of functional E-cadherin in the membrane. Treatment of the cells with HGF induced significant invasion into the matrigel. CONCLUSION: We can conclude that HGF can modulate the expression of E-cadherin in gastric carcinoma, which was accompanied by more aggressive phenotype. | en |
dc.language.iso | en | - |
dc.publisher | Lippincott Williams and Wilkins | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Biopsy, Needle | en |
dc.subject | Blotting, Western | en |
dc.subject | Cadherins/drug effects/*metabolism | en |
dc.subject | Carcinoma/metabolism/pathology/surgery | en |
dc.subject | Cell Proliferation | en |
dc.subject | Cohort Studies | en |
dc.subject | Female | en |
dc.subject | Hepatocyte Growth Factor/analysis/*metabolism | en |
dc.subject | Humans | en |
dc.subject | Immunohistochemistry | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Neoplasm Invasiveness/pathology | en |
dc.subject | Neoplasm Staging | en |
dc.subject | Probability | en |
dc.subject | Prognosis | en |
dc.subject | Sensitivity and Specificity | en |
dc.subject | Stomach Neoplasms/*metabolism/*pathology/surgery | en |
dc.subject | Tumor Cells, Cultured | en |
dc.subject | Tumor Markers, Biological/*analysis/metabolism | en |
dc.title | Modulation of E-cadherin by hepatocyte growth factor induces aggressiveness of gastric carcinoma | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 한상욱 | - |
dc.contributor.AlternativeAuthor | 이화영 | - |
dc.contributor.AlternativeAuthor | 이재호 | - |
dc.contributor.AlternativeAuthor | 김욱환 | - |
dc.contributor.AlternativeAuthor | 남현자 | - |
dc.contributor.AlternativeAuthor | 김홍 | - |
dc.contributor.AlternativeAuthor | 조용관 | - |
dc.contributor.AlternativeAuthor | 김명욱 | - |
dc.contributor.AlternativeAuthor | 이건욱 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.