Simvastatin inhibits cigarette smoking-induced emphysema and pulmonary hypertension in rat lungs

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Lee, Ji-Hyun; Lee, Dong-Soon; Kim, Eun-Kyung; Choe, Kang-Hyeon; Oh, Yeon-Mock; Shim, Tae-Sun; Kim, Sang-Eun; Lee, Yun-Song; Lee, Sang-Do
Issue Date
American Lung Association
Am J Respir Crit Care Med. 2005 Oct 15;172(8):987-93. Epub 2005 Jul 7.
Administration, OralAnalysis of VarianceAnimalsBiopsyChronic DiseaseDisease Models, AnimalDrug Evaluation, PreclinicalHydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology/*therapeuticuseHypertension, Pulmonary/etiology/*prevention & controlInflammationMaleMatrix Metalloproteinase 2/analysis/drug effects/immunologyMatrix Metalloproteinase 3/analysis/drug effects/immunologyNitric Oxide Synthase/drug effects/immunologyPulmonary Artery/drug effects/immunology/pathologyPulmonary Emphysema/etiology/*prevention & controlRatsRats, Sprague-DawleyRisk FactorsSimvastatin/pharmacology/*therapeutic useSmoking/*adverse effects/drug therapy/immunology/metabolism/pathologyTime Factors
RATIONALE: In cigarette smoking-induced chronic obstructive pulmonary disease, structural and functional derangements are characterized by parenchymal destruction and pulmonary hypertension. Statins are 3-hydroxy-3-methyl-glutaryl-coenzyme-A reductase inhibitors that have been used as lipid-lowering agents. These drugs also have additional pharmacologic properties, including antiinflammation, scavenging reactive oxygen species, restoring endothelial function, and antithrombogenesis, all of which can counteract the harmful effects of cigarette smoking. OBJECTIVE: We performed assays to determine whether simvastatin could attenuate lung damage induced by chronic cigarette smoking in rats. METHODS: In Sprague-Dawley rats exposed to cigarette smoke for 16 weeks, morphologic changes in the lungs and pulmonary arterial pressure were examined. MAIN RESULTS: Simvastatin inhibited lung parenchymal destruction and development of pulmonary hypertension, and also inhibited peribronchial and perivascular infiltration of inflammatory cells and induction of matrix metalloproteinase-9 activity in lung tissue. Simvastatin additionally prevented pulmonary vascular remodeling and the changes in endothelial nitric oxide synthase expression induced by smoking. In human lung microvascular endothelial cells, simvastatin increased expression of endothelial nitric oxide synthase mRNA. CONCLUSIONS: Simvastatin ameliorated the structural and functional derangements of the lungs caused by cigarette smoking, partly by suppressing inflammation and matrix metalloproteinase-9 induction and preventing pulmonary vascular abnormality. These findings indicate that statins may play a role in the treatment of cigarette smoking-induced chronic obstructive pulmonary disease.
1073-449X (Print)
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College of Medicine/School of Medicine (의과대학/대학원)Laboratory Medicine (검사의학전공)Journal Papers (저널논문_검사의학전공)
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