Publications
Detailed Information
Plasma level of stromal derived factor-1 (SDF-1) is increased in disseminated intravascular coagulation patients who have poor outcomes: in vitro effect of SDF-1 on coagulopathy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Hyun Kyung | - |
dc.contributor.author | Kim, Ji-Eun | - |
dc.contributor.author | Chung, Junho | - |
dc.contributor.author | Lee, Dong Soon | - |
dc.contributor.author | Han, Kyou-Sup | - |
dc.contributor.author | Park, Seonyang | - |
dc.contributor.author | Cho, Han-Ik | - |
dc.date.accessioned | 2009-11-26T07:40:05Z | - |
dc.date.available | 2009-11-26T07:40:05Z | - |
dc.date.issued | 2007-01-24 | - |
dc.identifier.citation | Thromb Res. 2007;120(4):559-66. Epub 2007 Jan 18. | en |
dc.identifier.issn | 0049-3848 (Print) | - |
dc.identifier.uri | http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T1C-4MVDVDC-1&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=af0289da6f3a27e4fc67d592dc48a0f1 | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17239427 | - |
dc.identifier.uri | https://hdl.handle.net/10371/16138 | - |
dc.description.abstract | Stromal cell-derived factor-1 (SDF-1) is a CXC chemokine that activates and directs the migration of leukocytes that have CXCR4, which is the unique receptor for SDF-1. Although SDF-1/CXCR4 interaction has been implicated in various inflammatory conditions, its role in modulating coagulation has not been determined. We studied the plasma SDF-1 levels in 90 patients with suspected disseminated intravascular coagulation (DIC) and we found that circulating SDF-1 was significantly increased in the overt DIC patients and was also increased in overt DIC patients who have a poor outcome. We then tested in vitro whether SDF-1 can affect the expression of monocyte tissue factor (TF) and endothelial thrombomodulin (TM), and both of these play important roles in coagulopathy. SDF-1 did not affect the expression of surface TF protein and its function and the TF mRNA level in both monocytes and the monocytic leukemia cell line THP-1. SDF-1 also did not change the surface TM expression of endothelial cells. SDF-1 could enhance low-dose ADP induced platelet aggregation, although it failed by itself to induce aggregation. These findings suggest that plasma SDF-1 might be closely associated with hypercoagulability though its action as a platelet activator. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Cells, Cultured | en |
dc.subject | Chemokine CXCL12 | en |
dc.subject | Chemokines, CXC/*blood/pharmacology | en |
dc.subject | Disseminated Intravascular Coagulation/*blood | en |
dc.subject | Endothelial Cells/metabolism | en |
dc.subject | Humans | en |
dc.subject | Monocytes/metabolism | en |
dc.subject | Platelet Function Tests | en |
dc.subject | Prognosis | en |
dc.subject | Thrombomodulin/drug effects | en |
dc.subject | Thrombophilia/*etiology | en |
dc.subject | Thromboplastin/drug effects | en |
dc.title | Plasma level of stromal derived factor-1 (SDF-1) is increased in disseminated intravascular coagulation patients who have poor outcomes: in vitro effect of SDF-1 on coagulopathy | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김현경 | - |
dc.contributor.AlternativeAuthor | 김지은 | - |
dc.contributor.AlternativeAuthor | 정준호 | - |
dc.contributor.AlternativeAuthor | 이동순 | - |
dc.contributor.AlternativeAuthor | 한규섭 | - |
dc.contributor.AlternativeAuthor | 박선양 | - |
dc.contributor.AlternativeAuthor | 조한익 | - |
dc.identifier.doi | 10.1016/j.thromres.2006.11.011 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.