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Aberrant theta-gamma frequency coupling in patients with first episode psychosis : 초발 정신증 환자에서 세타-감마 주파수 연결성 이상에 관한 연구
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 권준수 | - |
dc.contributor.author | 이탁형 | - |
dc.date.accessioned | 2019-10-21T03:30:04Z | - |
dc.date.available | 2019-10-21T03:30:04Z | - |
dc.date.issued | 2019-08 | - |
dc.identifier.other | 000000156420 | - |
dc.identifier.uri | https://hdl.handle.net/10371/162356 | - |
dc.identifier.uri | http://dcollection.snu.ac.kr/common/orgView/000000156420 | ko_KR |
dc.description | 학위논문(박사)--서울대학교 대학원 :자연과학대학 뇌인지과학과,2019. 8. 권준수. | - |
dc.description.abstract | Background: Although cognitive dysfunction has been suggested as one of the core pathologies of schizophrenia and affects patients daily functioning and quality of life, little is known about its neurobiological underpinnings, which would lead to and instigate the development of effective treatment methods. Since the resting-state activity is crucial for cognitive functioning and electroencephalography (EEG) can reflect moment-by-moment changes of neural activity with high temporal resolution, I aimed to investigate theta phase-gamma amplitude coupling (TGC) of resting-state EEG and its relationship with cognitive functioning in patients with first episode psychosis (FEP).
Methods: A total of 59 FEP patients and 50 healthy controls (HCs) participated in the resting-state EEG recording in eyes-closed state. In addition to the assessment of severity of clinical symptoms, the Trail Making Test Part A (TMT-A) and Part B (TMT-B), and the California Verbal Learning Test (CVLT) were used to measure cognitive functioning. The TGC from standardized low-resolution brain electromagnetic tomography (sLORETA) source signal of resting-state EEG was calculated in the default mode network (DMN)-related brain regions and was compared between the FEP and HC groups. Correlation analyses to reveal the relationship between TGC in FEP patients and the performance of neurocognitive function tests (NCFTs) were conducted. Results: Mean resting-state TGC was larger for the FEP group than for HCs. Patients with FEP showed greater TGC in the left posterior cingulate cortex (PCC), which was correlated with better performances in TMT-A and TMT-B, and with the immediate and delayed recall of the CVLT. Conclusion: Larger TGC in the brain regions comprising DMN in the FEP group compared to HCs indicates that patients with FEP may show compensatory hyperactivation of DMN-related brain regions during the resting-state, which may be related with reallocation of cognitive resources for preparing cognitive execution. This study not only highlights the moment-by-moment neural underpinnings of cognitive dysfunction in FEP patients but also provides useful background and insight in developing treatment methods for cognitive dysfunction of schizophrenia. | - |
dc.description.tableofcontents | Chapter 1. Introduction 1
Schizophrenia and cognitive dysfunction 1 Resting-state and cognitive function in schizophrenia 2 Neural oscillation and theta phase-gamma amplitude coupling (TGC) 5 Aims and hypothesis 7 Chapter 2. Methods 9 Participants 9 Neurocognitive function tests 10 EEG acquisition and pre-processing 10 Source analysis 13 Theta phase-gamma amplitude coupling 16 Statistical analysis 18 Chapter 3. Results 19 Characteristics of the participants 19 Theta-gamma coupling results 21 Correlation analysis results 28 Chapter 4. Discussion 33 Summary 33 Localized TGC in the DMN-related brain regions at the resting-state 34 Larger TGC in FEP patients in the left PCC 34 Correlation with NCFT results 35 TGC in the DMN-related brain regions during the resting-state in patients with FEP 37 Limitation 38 Chapter 5. Conclusion 39 Abstract in Korean 53 | - |
dc.language.iso | eng | - |
dc.publisher | 서울대학교 대학원 | - |
dc.subject | cross frequency coupling | - |
dc.subject | default mode network | - |
dc.subject | electroencephalography | - |
dc.subject | theta phase-gamma amplitude coupling | - |
dc.subject | resting-state | - |
dc.subject.ddc | 612.8233 | - |
dc.title | Aberrant theta-gamma frequency coupling in patients with first episode psychosis | - |
dc.title.alternative | 초발 정신증 환자에서 세타-감마 주파수 연결성 이상에 관한 연구 | - |
dc.type | Thesis | - |
dc.type | Dissertation | - |
dc.contributor.department | 자연과학대학 뇌인지과학과 | - |
dc.description.degree | Doctor | - |
dc.date.awarded | 2019-08 | - |
dc.identifier.uci | I804:11032-000000156420 | - |
dc.identifier.holdings | 000000000040▲000000000041▲000000156420▲ | - |
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