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Early Vitamin C and Thiamine Administration to Patients with Septic Shock in Emergency Departments: Propensity Score-Based Analysis of a Before-and-After Cohort Study
DC Field | Value | Language |
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dc.contributor.author | Shin, Tae Gun | - |
dc.contributor.author | Kim, Youn-Jung | - |
dc.contributor.author | Ryoo, Seung Mok | - |
dc.contributor.author | Hwang, Sung Yeon | - |
dc.contributor.author | Jo, Ik Joon | - |
dc.contributor.author | Chung, Sung Phil | - |
dc.contributor.author | Choi, Sung-Hyuk | - |
dc.contributor.author | Suh, Gil Joon | - |
dc.contributor.author | Kim, Won Young | - |
dc.creator | 서길준 | - |
dc.date.accessioned | 2020-01-23T07:31:36Z | - |
dc.date.available | 2020-04-05T07:31:36Z | - |
dc.date.created | 2020-01-28 | - |
dc.date.created | 2020-01-28 | - |
dc.date.issued | 2019-01 | - |
dc.identifier.citation | Journal of Clinical Medicine, Vol.8 No.1, p. 102 | - |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.uri | https://hdl.handle.net/10371/163796 | - |
dc.description.abstract | Background: Intravenous vitamin C and thiamine administration may be a potential adjuvant therapy for septic shock. We aimed to investigate the impact of early vitamin C and thiamine administration in septic shock patients. Methods: This retrospective before-and-after cohort study used data extracted from the Korean Shock Society's prospective septic shock registry. We compared 28-day and in-hospital mortality rates between patients treated with intravenous vitamin C (3 g/12 h or 1.5 g/6 h) and thiamine (200 mg/12 h) <6 h after shock recognition from July through December 2017 (n = 229) and control patients from October 2015 through June 2017 (n = 915) using propensity score matching. Results: The 28-day (18.3% vs. 17.5%; p = 0.76) and in-hospital (16.6% vs. 18.3%; p = 0.55) mortality rates did not differ between treatment and control groups, nor did 28-day (18.5% vs. 17.5%; p = 0.84) and in-hospital (16.7% vs. 18.4%; p = 0.54) mortality rates after matching. In the subgroup analysis, treatment was associated with lower in-hospital mortality rates in patients with albumin <3.0 mg/dL or a Sequential Organ Failure Assessment (SOFA) score >10. Conclusion: Early vitamin C and thiamine administration in patients with septic shock did not improve survival; however, administration could benefit conditions that are more severe, such as hypoalbuminemia or severe organ failure. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | en |
dc.publisher | MDPI AG | - |
dc.title | Early Vitamin C and Thiamine Administration to Patients with Septic Shock in Emergency Departments: Propensity Score-Based Analysis of a Before-and-After Cohort Study | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/jcm8010102 | - |
dc.citation.journaltitle | Journal of Clinical Medicine | - |
dc.identifier.wosid | 000457141100101 | - |
dc.identifier.scopusid | 2-s2.0-85069839053 | - |
dc.description.srnd | OAIID:RECH_ACHV_DSTSH_NO:T201913787 | - |
dc.description.srnd | RECH_ACHV_FG:RR00200001 | - |
dc.description.srnd | ADJUST_YN: | - |
dc.description.srnd | EMP_ID:A076403 | - |
dc.description.srnd | CITE_RATE:5.583 | - |
dc.description.srnd | DEPT_NM:의학과 | - |
dc.description.srnd | EMAIL:suhgil@snu.ac.kr | - |
dc.description.srnd | SCOPUS_YN:Y | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 102 | - |
dc.citation.volume | 8 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Suh, Gil Joon | - |
dc.identifier.srnd | T201913787 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | CAMPAIGN INTERNATIONAL GUIDELINES | - |
dc.subject.keywordPlus | ASCORBIC-ACID | - |
dc.subject.keywordPlus | ORGAN FAILURE | - |
dc.subject.keywordPlus | SEVERE SEPSIS | - |
dc.subject.keywordPlus | HYDROCORTISONE | - |
dc.subject.keywordPlus | RESUSCITATION | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | TRIAL | - |
dc.subject.keywordPlus | STEP | - |
dc.subject.keywordAuthor | sepsis | - |
dc.subject.keywordAuthor | septic shock | - |
dc.subject.keywordAuthor | thiamine | - |
dc.subject.keywordAuthor | vitamin C | - |
dc.subject.keywordAuthor | resuscitation | - |
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