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Promotive effect of minoxidil combined with all-trans retinoic acid (tretinoin) on human hair growth in vitro

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dc.contributor.authorKwon, Oh Sang-
dc.contributor.authorPyo, Hyun Keol-
dc.contributor.authorOh, Youn Jin-
dc.contributor.authorHan, Ji Hyun-
dc.contributor.authorLee, Se Rah-
dc.contributor.authorChung, Jin Ho-
dc.contributor.authorEun, Hee Chul-
dc.contributor.authorKim, Kyu Han-
dc.date.accessioned2009-11-27T03:52:00Z-
dc.date.available2009-11-27T03:52:00Z-
dc.date.issued2007-04-24-
dc.identifier.citationJ Korean Med Sci. 2007 Apr;22(2):283-9.en
dc.identifier.issn1011-8934 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17449938-
dc.identifier.urihttp://hdl.handle.net/10371/16436-
dc.description.abstractMinoxidil induces hair growth in male pattern baldness and prolongs the anagen phase. All-trans retinoic acid (ATRA) has been reported to act synergistically with minoxidil in vivo: they can enhance more dense hair regrowth than either compound alone. We evaluated the effect of minoxidil combined with ATRA on hair growth in vitro. The effect of co-treatment of minoxidil and ATRA on hair growth was studied in hair follicle organ culture. In cultured human dermal papilla cells (DPCs) and normal human epidermal keratinocytes, the expressions of Erk, Akt, Bcl-2, Bax, P53 and P21 were evaluated by immunoblot analysis. Minoxidil plus ATRA additively promoted hair growth in vitro, compared with minoxidil alone. In addition, minoxidil plus ATRA elevated phosphorylated Erk, phosphorylated Akt and the ratio of Bcl-2/Bax, but decreased the expressions of P53 and P21 more effectively than by minoxidil alone. Our results suggest that minoxidil plus ATRA would additively enhance hair growth by mediating dual functions: 1) the prolongation of cell survival by activating the Erk and Akt signaling pathways, and 2) the prevention of apoptosis of DPCs and epithelial cells by increasing the ratio of Bcl-2/Bax and downregulating the expressions of P53 and P21.en
dc.language.isoen-
dc.publisherKorean Academy of Medical Scienceen
dc.subjectCell Proliferation/drug effectsen
dc.subjectCells, Cultureden
dc.subjectDose-Response Relationship, Drugen
dc.subjectDrug Combinationsen
dc.subjectHair/cytology/*drug effects/*growth & developmenten
dc.subjectHumansen
dc.subjectKeratolytic Agents/administration & dosageen
dc.subjectMinoxidil/*administration & dosageen
dc.subjectTretinoin/*administration & dosageen
dc.titlePromotive effect of minoxidil combined with all-trans retinoic acid (tretinoin) on human hair growth in vitroen
dc.typeArticleen
dc.contributor.AlternativeAuthor권오상-
dc.contributor.AlternativeAuthor표현걸-
dc.contributor.AlternativeAuthor한지현-
dc.contributor.AlternativeAuthor오윤진-
dc.contributor.AlternativeAuthor이세라-
dc.contributor.AlternativeAuthor정진호-
dc.contributor.AlternativeAuthor은희철-
dc.contributor.AlternativeAuthor김규한-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dermatology (피부과학전공)Journal Papers (저널논문_피부과학전공)
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