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Body Mass Index Is Not Associated with Treatment Outcomes of Breast Cancer Patients Receiving Neoadjuvant Chemotherapy: Korean Data

Cited 6 time in Web of Science Cited 7 time in Scopus
Authors
Lee, Kytmg-Hun; Keam, Bhumsuk; Im, Seock-Ah; Kim, Tae-Yong; Han, Sae-Won; Oh, Do-Youn; Kim, Jee Hyun; Lee, Se-Hoon; Han, Wonshik; Kim, Dong-Wan; Kim, Tae-You; Park, In Ae; Noh, Dong-Young; Heo, Dae Seog; Bang, Yung-Jue
Issue Date
2012-12
Citation
Journal of Breast Cancer, Vol.15 No.4, pp.427-433
Keywords
Breast neoplasmsNeoadjuvant therapyObesityPrognosis
Abstract
Purpose: The effects of body mass index on pathologic complete response and survival have not been reported in Korean patients with breast cancer. The purpose of this study was to evaluate the predictive or prognostic value of obesity in breast cancer receiving neoadjuvant chemotherapy. Methods: A total of 438 stage II or III breast cancer patients treated with neoadjuvant chemotherapy were enrolled and analyzed retrospectively. Results: In the study, 319 patients (72.8%) were normal weight, 100 patients (22.8%) were overweight, and 19 patients (4.3%) were obese. Baseline clinicopathologic characteristics were not different among the groups, except for age. There were no differences in pathologic complete response rate between the groups (9.7% in normal weight, 10.0% in overweight, 5.3% in obese; p=0.804). Neither overweight nor obese patients showed a significant difference in relapse-free survival compared to normal weight patients (p=0.523 and p=0.931, respectively). Also, no significant difference in overall survival (p=0.520 and p=0.864, respectively) was observed. Conclusion: Obesity or higher body mass index was not significantly associated with pathologic complete response and survival in Korean patients with breast cancer who received neoadjuvant chemotherapy. Our results suggest that the prognostic impact of body mass index is different from that of Western patients.
ISSN
1738-6756
URI
http://hdl.handle.net/10371/165486
DOI
https://doi.org/10.4048/jbc.2012.15.4.427
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College of Medicine/School of Medicine (의과대학/대학원)Cancer Research Institute (암연구소)Journal Papers (저널논문_암연구소)
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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