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Activity of Crizotinib (PF02341066), a Dual Mesenchymal-Epithelial Transition (MET) and Anaplastic Lymphoma Kinase (ALK) Inhibitor, in a Non-small Cell Lung Cancer Patient with De Novo MET Amplification
Cited 353 time in
Web of Science
Cited 392 time in Scopus
- Authors
- Issue Date
- 2011-05
- Publisher
- Elsevier Inc.
- Citation
- Journal of Thoracic Oncology, Vol.6 No.5, pp.942-946
- Abstract
- Crizotinib is a dual MET and ALK inhibitor. Currently, clinical development of crizotinib is focused primarily on ALK rearranged non-small cell lung cancer (NSCLC). Here we report an NSCLC patient with de novo MET amplification but no ALK rearrangement who achieved a rapid and durable response to crizotinib indicating is also a bona fide MET inhibitor.
- ISSN
- 1556-0864
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