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First-line therapy with doxycycline in ocular adnexal mucosa-associated lymphoid tissue lymphoma: A retrospective analysis of clinical predictors
DC Field | Value | Language |
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dc.contributor.author | Kim, Tae Min | - |
dc.contributor.author | Kim, Ki Hwan | - |
dc.contributor.author | Lee, Min Joung | - |
dc.contributor.author | Jeon, Yoon Kyung | - |
dc.contributor.author | Lee, Se-Hoon | - |
dc.contributor.author | Kim, Dong-Wan | - |
dc.contributor.author | Kim, Chul Woo | - |
dc.contributor.author | Kim, Il Han | - |
dc.contributor.author | Khwarg, Sang In | - |
dc.contributor.author | Heo, Dae Seog | - |
dc.date.accessioned | 2020-04-27T11:38:43Z | - |
dc.date.available | 2020-04-27T11:38:43Z | - |
dc.date.created | 2020-02-19 | - |
dc.date.issued | 2010-05 | - |
dc.identifier.citation | Cancer Science, Vol.101 No.5, pp.1199-1203 | - |
dc.identifier.issn | 1347-9032 | - |
dc.identifier.other | 91849 | - |
dc.identifier.uri | https://hdl.handle.net/10371/165546 | - |
dc.description.abstract | This retrospective study was launched to evaluate the efficacy of doxycycline and to find independent predictors of a clinical response in patients with ocular adnexal lymphoma of mucosa‐associated lymphoid tissue (OAML). Thirty‐eight patients with newly diagnosed, localized OAML received doxycycline for 3 weeks (12 patients) or 6 weeks (26 patients). Clinical factors including absolute lymphocyte count (ALC) and neutrophil count (ANC) were compared between responders and non‐responders. After a median follow‐up of 26.4 months, doxycycline resulted in an overall response rate of 47% and a 3‐year time‐to‐treatment failure (TTF) rate of 84%. Patients treated with doxycycline for 6 weeks versus 3 weeks tended to have a higher response rate (54%vs 33%). Absolute lymphocytosis (ALC > 3.01 × 109/L) and absolute neutrophilia (ANC > 1.92 × 109/L) were defined based on the median value of each count. Patients with (19 patients) versus without absolute lymphocytosis had significantly shorter 2‐year TTF (70%vs 100%, P = 0.021) and a lower response rate (32%vs 63%, P = 0.051). Absolute lymphocytosis (odds ratio [OR] = 4.7; 95% confidence interval [CI], 1.1–20.8; P = 0.043) and non‐conjunctival tumor (OR = 11.8; 95% CI, 1.1–122.5; P = 0.038) were negative predictors for response by multivariate analysis. Front‐line doxycycline is effective particularly in localized OAML patients without absolute lymphocytosis but with conjunctival involvement.
(Cancer Sci 2010; 101: 1199–1203) | - |
dc.language | 영어 | - |
dc.publisher | Oxford University Press | - |
dc.title | First-line therapy with doxycycline in ocular adnexal mucosa-associated lymphoid tissue lymphoma: A retrospective analysis of clinical predictors | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 김철우 | - |
dc.contributor.AlternativeAuthor | 전윤경 | - |
dc.contributor.AlternativeAuthor | 김동완 | - |
dc.contributor.AlternativeAuthor | 곽상인 | - |
dc.contributor.AlternativeAuthor | 허대석 | - |
dc.contributor.AlternativeAuthor | 김일한 | - |
dc.identifier.doi | 10.1111/j.1349-7006.2010.01502.x | - |
dc.citation.journaltitle | Cancer Science | - |
dc.identifier.wosid | 000276853900019 | - |
dc.identifier.scopusid | 2-s2.0-77953197341 | - |
dc.citation.endpage | 1203 | - |
dc.citation.number | 5 | - |
dc.citation.startpage | 1199 | - |
dc.citation.volume | 101 | - |
dc.identifier.sci | 000276853900019 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Jeon, Yoon Kyung | - |
dc.contributor.affiliatedAuthor | Kim, Dong-Wan | - |
dc.contributor.affiliatedAuthor | Kim, Chul Woo | - |
dc.contributor.affiliatedAuthor | Kim, Il Han | - |
dc.contributor.affiliatedAuthor | Khwarg, Sang In | - |
dc.contributor.affiliatedAuthor | Heo, Dae Seog | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ERADICATING ANTIBIOTIC-THERAPY | - |
dc.subject.keywordPlus | B-CELL LYMPHOMA | - |
dc.subject.keywordPlus | CHLAMYDIA-PSITTACI | - |
dc.subject.keywordPlus | MALT LYMPHOMA | - |
dc.subject.keywordPlus | PROGNOSTIC-FACTORS | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordPlus | PNEUMONIAE | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | COMMITTEE | - |
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