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Class III beta-tubulin, but not ERCC1, is a strong predictive and prognostic marker in locally advanced head and neck squamous cell carcinoma

Cited 44 time in Web of Science Cited 54 time in Scopus
Authors
Koh, Y.; Kim, T. M.; Jeon, Yoon Kyung; Kwon, Tack-Kyun; Hah, J. Hun; Lee, S. -H.; Kim, Dong-Wan; Wu, Hong-Gyun; Rhee, Chae-Seo; Sung, Myung-Whun; Kim, Chul Woo; Kim, Kwang Hyun; Heo, Dae Seog
Issue Date
2009-08
Citation
Annals of Oncology, Vol.20 No.8, pp.1414-1419
Keywords
beta-TubulinERCC1head and neck cancerlocally advancedprognosis
Abstract
Materials and methods: Retrospective review of medical records at Seoul National University Hospital between 1998 and 2007 was carried out. Immunohistochemical stain of TUBB3, p53, and ERCC1 was done in paraffin-embedded tumor tissue. We assessed response to treatment, progression-free survival (PFS), overall survival (OS), and cancer-specific survival (CSS). Results: Eighty-five patients with oropharyngeal, hypopharyngeal, and laryngeal cancers received induction chemotherapy with 5-fluorouracil (5-FU) and cisplatin (n = 55), or 5-FU, cisplatin, and docetaxel (Taxotere) (n = 30). Eighty-three received definitive treatment after induction chemotherapy, where 62 received radiotherapy and 21 received surgery. TUBB3-positive patients showed lower response rate than TUBB3-negative patients (69% versus 88%, P = 0.039). Shorter median PFS was observed in TUBB3-positive group (12 versus 47 months, P = 0.001). Shorter median OS was observed in TUBB-positive group not reaching statistical significance (30 versus 59 months, P = 0.072). TUBB3 status significantly influenced CSS (35 months versus not reached, P = 0.017). Positive p53 status was related to poorer OS and CSS. ERCC1 showed no influence on chemotherapy response, PFS, OS, and CSS. Conclusion: TUBB3 is a predictive and prognostic marker along with well-known p53 in HNSCC patients receiving cisplatin-based induction chemotherapy. Clinical impact of ERCC1 is not evident in this setting.
ISSN
0923-7534
URI
http://hdl.handle.net/10371/165552
DOI
https://doi.org/10.1093/annonc/mdp002
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College of Medicine/School of Medicine (의과대학/대학원)Cancer Research Institute (암연구소)Journal Papers (저널논문_암연구소)
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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