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Reduced dose intensity FOLFOX-4 as first line palliative chemotherapy in elderly patients with advanced colorectal cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jee Hyun | - |
dc.contributor.author | Oh, Do Youn | - |
dc.contributor.author | Kim, Yu Jung | - |
dc.contributor.author | Han, Sae Won | - |
dc.contributor.author | Choi, In-Sil | - |
dc.contributor.author | Kim, Dong Wan | - |
dc.contributor.author | Im, Seock Ah | - |
dc.contributor.author | Kim, Tae You | - |
dc.contributor.author | Lee, Jong Seok | - |
dc.contributor.author | Heo, Dae Seog | - |
dc.contributor.author | Bang, Yung-Jue | - |
dc.contributor.author | Kim, Noe Kyeong | - |
dc.date.accessioned | 2020-04-27T11:45:53Z | - |
dc.date.available | 2020-04-27T11:45:53Z | - |
dc.date.created | 2020-04-08 | - |
dc.date.created | 2020-04-08 | - |
dc.date.created | 2020-04-08 | - |
dc.date.created | 2020-04-08 | - |
dc.date.issued | 2005-10 | - |
dc.identifier.citation | Journal of Korean Medical Science, Vol.20 No.5, pp.806-810 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.other | 95317 | - |
dc.identifier.uri | https://hdl.handle.net/10371/165566 | - |
dc.description.abstract | To evaluate the toxicity and efficacy of a reduced dose intensity (mini-) FOLFOX-4 regimen as a first-line palliative chemotherapy in elderly patients (>= 70 yr of age) with advanced colorectal cancer, data from prospective databases at Seoul National University Bundang Hospital and Seoul Municipal Boramae Hospital were analyzed. A total of 20 patients were enrolled between January 2001 and August 2004, and were treated with oxaliplatin 65 mg/m(2) on day 1, and with 2-hr infusions of leucovorin 150 mg/m(2) followed by a 5-FU bolus (300 mg/m(2)) and 22-hr continuous infusions (450 mg/m(2)) for 2 consecutive days every 2 weeks until progression, unacceptable toxicity or patient refusal. Sixteen patients were evaluable for response with an overall response rate of 43.8%. Median progression-free survival was 4.8 months (95% CI: 3.0-6.7) and overall survival was 13.5 months (95% Cl: 11.1-16.0). The main side effects were anemia and neutropenia, which were observed in 20.8% and 117.7%, respectively, of the total cycles administered. There were no grade 4 toxicities an only one patient suffered from febrile neutropenia. No grade 3 toxicities occurred except for anemia (5.2%) and vomiting (1.0%). In conclusion, the mini-FOLFOX-4 regimen was found to be well tolerated with acceptable toxicity, and to provide a benefit for elderly patients with colorectal cancer. | - |
dc.language | 영어 | - |
dc.publisher | 대한의학회 | - |
dc.title | Reduced dose intensity FOLFOX-4 as first line palliative chemotherapy in elderly patients with advanced colorectal cancer | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 임석아 | - |
dc.identifier.doi | 10.3346/jkms.2005.20.5.806 | - |
dc.citation.journaltitle | Journal of Korean Medical Science | - |
dc.identifier.wosid | 000233095100015 | - |
dc.identifier.scopusid | 2-s2.0-27744452928 | - |
dc.citation.endpage | 810 | - |
dc.citation.number | 5 | - |
dc.citation.startpage | 806 | - |
dc.citation.volume | 20 | - |
dc.identifier.sci | 000233095100015 | - |
dc.identifier.kciid | ART001195286 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Kim, Jee Hyun | - |
dc.contributor.affiliatedAuthor | Oh, Do Youn | - |
dc.contributor.affiliatedAuthor | Kim, Dong Wan | - |
dc.contributor.affiliatedAuthor | Im, Seock Ah | - |
dc.contributor.affiliatedAuthor | Kim, Tae You | - |
dc.contributor.affiliatedAuthor | Lee, Jong Seok | - |
dc.contributor.affiliatedAuthor | Heo, Dae Seog | - |
dc.contributor.affiliatedAuthor | Bang, Yung-Jue | - |
dc.contributor.affiliatedAuthor | Kim, Noe Kyeong | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | 5-FLUOROURACIL-BASED CHEMOTHERAPY | - |
dc.subject.keywordPlus | OLDER PATIENTS | - |
dc.subject.keywordPlus | COLON-CANCER | - |
dc.subject.keywordPlus | OXALIPLATIN | - |
dc.subject.keywordPlus | FLUOROURACIL | - |
dc.subject.keywordPlus | ADJUVANT | - |
dc.subject.keywordPlus | TRIALS | - |
dc.subject.keywordPlus | LEUCOVORIN | - |
dc.subject.keywordAuthor | aged | - |
dc.subject.keywordAuthor | colorectal neoplasms | - |
dc.subject.keywordAuthor | antineoplastic combined chemotherapy protocols | - |
dc.subject.keywordAuthor | Folfox protocol | - |
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