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Toward a functional annotation of the human genome using artificial transcription factors
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Dong-Ki | - |
dc.contributor.author | Park, Jin Woo | - |
dc.contributor.author | Kim, Youn-Jae | - |
dc.contributor.author | Kim, Jiwon | - |
dc.contributor.author | Lee, Yangsoon | - |
dc.contributor.author | Kim, Jeonglim | - |
dc.contributor.author | Kim, Jin-Soo | - |
dc.date.accessioned | 2020-04-27T12:28:15Z | - |
dc.date.available | 2020-04-27T12:28:15Z | - |
dc.date.created | 2020-03-24 | - |
dc.date.created | 2020-03-24 | - |
dc.date.issued | 2003-12 | - |
dc.identifier.citation | Genome Research, Vol.13 No.12, pp.2708-2716 | - |
dc.identifier.issn | 1088-9051 | - |
dc.identifier.other | 93241 | - |
dc.identifier.uri | https://hdl.handle.net/10371/165600 | - |
dc.description.abstract | We have developed a novel, high-throughput approach to collecting randomly perturbed gene-expression profiles from the human genome. A human 293 cell library that stably expresses randomly chosen zinc-finger transcription factors was constructed, and the expression profile of each cell line was obtained using cDNA microarray technology. Gene expression profiles from a total of 132 cell lines were collected and analyzed by (1) a simple clustering method based on expression-profile similarity, and (2) the shortest-path analysis method. These analyses identified a number of gene groups, and further investigation revealed that the genes that were grouped together had close biological relationships. The artificial transcription factor-based random genome perturbation method thus provides a novel functional genomic tool for annotation and classification of genes in the human genome and those of many other organisms. | - |
dc.language | 영어 | - |
dc.publisher | Cold Spring Harbor Laboratory Press | - |
dc.title | Toward a functional annotation of the human genome using artificial transcription factors | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 김진수 | - |
dc.identifier.doi | 10.1101/gr.1397903 | - |
dc.citation.journaltitle | Genome Research | - |
dc.identifier.wosid | 000186920200021 | - |
dc.identifier.scopusid | 2-s2.0-0348013054 | - |
dc.citation.endpage | 2716 | - |
dc.citation.number | 12 | - |
dc.citation.startpage | 2708 | - |
dc.citation.volume | 13 | - |
dc.identifier.sci | 000186920200021 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Kim, Jin-Soo | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | PROTEIN PHOSPHATASE 2A | - |
dc.subject.keywordPlus | DNA-BINDING PROTEINS | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | SACCHAROMYCES-CEREVISIAE | - |
dc.subject.keywordPlus | GROWTH-FACTOR | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | DROSOPHILA | - |
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