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Phenotypic alteration and target gene identification using combinatorial libraries of zinc finger proteins in prokaryotic cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Kyung-Soon | - |
dc.contributor.author | Jang, Young-Soon | - |
dc.contributor.author | Lee, Horim | - |
dc.contributor.author | Kim, Jin-Soo | - |
dc.date.accessioned | 2020-04-27T12:29:25Z | - |
dc.date.available | 2020-04-27T12:29:25Z | - |
dc.date.created | 2020-03-24 | - |
dc.date.created | 2020-03-24 | - |
dc.date.issued | 2005-08 | - |
dc.identifier.citation | Journal of Bacteriology, Vol.187 No.15, pp.5496-5499 | - |
dc.identifier.issn | 0021-9193 | - |
dc.identifier.other | 93235 | - |
dc.identifier.uri | https://hdl.handle.net/10371/165604 | - |
dc.description.abstract | We have developed a method with prokaryotic organisms that uses randomized libraries of zinc finger-containing artificial transcription factors to induce phenotypic variations and to identify genes involved in the generation of a specific phenotype of interest. Combining chromatin immunoprecipitation experiments and in silico prediction of target DNA binding sequences for the artificial transcription factors, we identified ubiX, whose down-regulation correlates with the thermotolerance phenotype in Escherichia coli. Our results show that randomized libraries of artificial transcription factors are powerful tools for functional genomic studies. | - |
dc.language | 영어 | - |
dc.publisher | American Society for Microbiology | - |
dc.title | Phenotypic alteration and target gene identification using combinatorial libraries of zinc finger proteins in prokaryotic cells | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 김진수 | - |
dc.identifier.doi | 10.1128/JB.187.15.5496-5499.2005 | - |
dc.citation.journaltitle | Journal of Bacteriology | - |
dc.identifier.wosid | 000230716800049 | - |
dc.identifier.scopusid | 2-s2.0-22544461606 | - |
dc.citation.endpage | 5499 | - |
dc.citation.number | 15 | - |
dc.citation.startpage | 5496 | - |
dc.citation.volume | 187 | - |
dc.identifier.sci | 000230716800049 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Kim, Jin-Soo | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ARTIFICIAL TRANSCRIPTION FACTORS | - |
dc.subject.keywordPlus | HUMAN GENOME | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.subject.keywordPlus | SITE | - |
dc.subject.keywordPlus | DNA | - |
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