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Genome editing comes of age
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jin-Soo | - |
dc.date.accessioned | 2020-04-27T12:48:48Z | - |
dc.date.available | 2020-04-27T12:48:48Z | - |
dc.date.created | 2018-09-14 | - |
dc.date.created | 2018-09-14 | - |
dc.date.issued | 2016-09 | - |
dc.identifier.citation | Nature Protocols, Vol.11 No.9, pp.1573-1578 | - |
dc.identifier.issn | 1754-2189 | - |
dc.identifier.other | 54128 | - |
dc.identifier.uri | https://hdl.handle.net/10371/165669 | - |
dc.description.abstract | Genome editing harnesses programmable nucleases to cut and paste genetic information in a targeted manner in living cells and organisms. Here, I review the development of programmable nucleases, including zinc finger nucleases (ZFNs), TAL (transcription-activator-like) effector nucleases (TALENs) and CRISPR (cluster of regularly interspaced palindromic repeats)-Cas9 (CRISPR-associated protein 9) RNA-guided endonucleases (RGENs). I specifically highlight the key advances that set the foundation for the rapid and widespread implementation of CRISPR-Cas9 genome editing approaches that has revolutionized the field. | - |
dc.language | 영어 | - |
dc.publisher | Nature Publishing Group | - |
dc.title | Genome editing comes of age | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 김진수 | - |
dc.identifier.doi | 10.1038/nprot.2016.104 | - |
dc.citation.journaltitle | Nature Protocols | - |
dc.identifier.wosid | 000382164800001 | - |
dc.identifier.scopusid | 2-s2.0-84981283748 | - |
dc.citation.endpage | 1578 | - |
dc.citation.number | 9 | - |
dc.citation.startpage | 1573 | - |
dc.citation.volume | 11 | - |
dc.identifier.sci | 000382164800001 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Jin-Soo | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ZINC-FINGER NUCLEASES | - |
dc.subject.keywordPlus | CRISPR-CAS SYSTEM | - |
dc.subject.keywordPlus | RNA-GUIDED ENDONUCLEASES | - |
dc.subject.keywordPlus | DNA-BINDING SPECIFICITY | - |
dc.subject.keywordPlus | DOUBLE-STRAND BREAKS | - |
dc.subject.keywordPlus | OFF-TARGET ACTIVITY | - |
dc.subject.keywordPlus | HUMAN-CELLS | - |
dc.subject.keywordPlus | GENE KNOCKOUT | - |
dc.subject.keywordPlus | RESTRICTION-ENDONUCLEASE | - |
dc.subject.keywordPlus | CAENORHABDITIS-ELEGANS | - |
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