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GATA Factor-Regulated Samd14 Enhancer Confers Red Blood Cell Regeneration and Survival in Severe Anemia
DC Field | Value | Language |
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dc.contributor.author | Hewitt, Kyle J. | - |
dc.contributor.author | Katsumura, Koichi R. | - |
dc.contributor.author | Matson, Daniel R. | - |
dc.contributor.author | Devadas, Prithvia | - |
dc.contributor.author | Tanimura, Nobuyuki | - |
dc.contributor.author | Hebert, Alexander S. | - |
dc.contributor.author | Coon, Joshua J. | - |
dc.contributor.author | Kim, Jin-Soo | - |
dc.contributor.author | Dewey, Colin N. | - |
dc.contributor.author | Keles, Sunduz | - |
dc.contributor.author | Hao, Siyang | - |
dc.contributor.author | Paulson, Robert F. | - |
dc.contributor.author | Bresnick, Emery H. | - |
dc.date.accessioned | 2020-04-27T12:50:00Z | - |
dc.date.available | 2020-04-27T12:50:00Z | - |
dc.date.created | 2018-09-13 | - |
dc.date.created | 2018-09-13 | - |
dc.date.issued | 2017-08 | - |
dc.identifier.citation | Developmental Cell, Vol.42 No.3, pp.213-225.e4 | - |
dc.identifier.issn | 1534-5807 | - |
dc.identifier.other | 53683 | - |
dc.identifier.uri | https://hdl.handle.net/10371/165673 | - |
dc.description.abstract | An enhancer with amalgamated E-box and GATA motifs (+9.5) controls expression of the regulator of hematopoiesis GATA-2. While similar GATA-2-occupied elements are common in the genome, occupancy does not predict function, and GATA-2-dependent genetic networks are incompletely defined. A "+9.5-like" element resides in an intron of Samd14 (Samd14-Enh) encoding a sterile alpha motif (SAM) domain protein. Deletion of Samd14-Enh in mice strongly decreased Samd14 expression in bone marrow and spleen. Although steady-state hematopoiesis was normal, Samd14-Enh(-/-) mice died in response to severe anemia. Samd14-Enh stimulated stem cell factor/c-Kit signaling, which promotes erythrocyte regeneration. Anemia activated Samd14-Enh by inducing enhancer components and enhancer chromatin accessibility. Thus, a GATA-2/anemia-regulated enhancer controls expression of an SAM domain protein that confers survival in anemia. We propose that Samd14-Enh and an ensemble of anemia-responsive enhancers are essential for erythrocyte regeneration in stress erythropoiesis, a vital process in pathologies, including beta-thalassemia, myelodysplastic syndrome, and viral infection. | - |
dc.language | 영어 | - |
dc.publisher | Cell Press | - |
dc.title | GATA Factor-Regulated Samd14 Enhancer Confers Red Blood Cell Regeneration and Survival in Severe Anemia | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 김진수 | - |
dc.identifier.doi | 10.1016/j.devcel.2017.07.009 | - |
dc.citation.journaltitle | Developmental Cell | - |
dc.identifier.wosid | 000407040900006 | - |
dc.identifier.scopusid | 2-s2.0-85026544988 | - |
dc.citation.endpage | 225.e4 | - |
dc.citation.number | 3 | - |
dc.citation.startpage | 213 | - |
dc.citation.volume | 42 | - |
dc.identifier.sci | 000407040900006 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Kim, Jin-Soo | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ACUTE MYELOID-LEUKEMIA | - |
dc.subject.keywordPlus | STRESS ERYTHROID PROGENITORS | - |
dc.subject.keywordPlus | CHROMATIN OCCUPANCY ANALYSIS | - |
dc.subject.keywordPlus | GENOME-WIDE ANALYSIS | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR | - |
dc.subject.keywordPlus | HEMATOPOIETIC STEM | - |
dc.subject.keywordPlus | EXTRAMEDULLARY ERYTHROPOIESIS | - |
dc.subject.keywordPlus | MUTANT MICE | - |
dc.subject.keywordPlus | CIS-ELEMENT | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordAuthor | anemia | - |
dc.subject.keywordAuthor | enhancer | - |
dc.subject.keywordAuthor | erythroid | - |
dc.subject.keywordAuthor | GATA-2 | - |
dc.subject.keywordAuthor | hematopoiesis | - |
dc.subject.keywordAuthor | regeneration | - |
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