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Precision genome engineering through adenine and cytosine base editing
Cited 59 time in
Web of Science
Cited 60 time in Scopus
- Authors
- Issue Date
- 2018-03
- Publisher
- Palgrave Macmillan Ltd.
- Citation
- Nature Plants, Vol.4 No.3, pp.148-151
- Abstract
- Adenine base editors (ABEs), composed of an engineered deaminase and a catalytically impaired CRISPR-Cas9 variant, are powerful new tools for targeted base editing in cells and organisms. Together with cytosine base editors (CBEs), ABEs enable single-nucleotide conversions cleanly, efficiently and reversibly without double-stranded DNA cleavage, advancing genome editing in a new dimension.
- ISSN
- 2055-026X
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