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Telomere maintenance through recruitment of internal genomic regions
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Seo, Beomseok | - |
dc.contributor.author | Kim, Chuna | - |
dc.contributor.author | Hills, Mark | - |
dc.contributor.author | Sung, Sanghyun | - |
dc.contributor.author | Kim, Hyesook | - |
dc.contributor.author | Kim, Eunkyeong | - |
dc.contributor.author | Lim, Daisy S. | - |
dc.contributor.author | Oh, Hyun-Seok | - |
dc.contributor.author | Choi, Rachael Mi Jung | - |
dc.contributor.author | Chun, Jongsik | - |
dc.contributor.author | Shim, Jaegal | - |
dc.contributor.author | Lee, Junho | - |
dc.date.accessioned | 2020-04-27T13:17:52Z | - |
dc.date.available | 2020-04-27T13:17:52Z | - |
dc.date.created | 2018-10-31 | - |
dc.date.created | 2018-10-31 | - |
dc.date.issued | 2015-09 | - |
dc.identifier.citation | Nature Communications, Vol.6, p. 8189 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.other | 64856 | - |
dc.identifier.uri | https://hdl.handle.net/10371/165755 | - |
dc.description.abstract | Cells surviving crisis are often tumorigenic and their telomeres are commonly maintained through the reactivation of telomerase. However, surviving cells occasionally activate a recombination-based mechanism called alternative lengthening of telomeres (ALT). Here we establish stably maintained survivors in telomerase-deleted Caenorhabditis elegans that escape from sterility by activating ALT. ALT survivors trans-duplicate an internal genomic region, which is already cis-duplicated to chromosome ends, across the telomeres of all chromosomes. These 'Template for ALT' (TALT) regions consist of a block of genomic DNA flanked by telomere-like sequences, and are different between two genetic background. We establish a model that an ancestral duplication of a donor TALT region to a proximal telomere region forms a genomic reservoir ready to be incorporated into telomeres on ALT activation. | - |
dc.language | 영어 | - |
dc.publisher | Nature Publishing Group | - |
dc.title | Telomere maintenance through recruitment of internal genomic regions | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 이준호 | - |
dc.contributor.AlternativeAuthor | 천종식 | - |
dc.identifier.doi | 10.1038/ncomms9189 | - |
dc.citation.journaltitle | Nature Communications | - |
dc.identifier.wosid | 000363017100016 | - |
dc.identifier.scopusid | 2-s2.0-84942016751 | - |
dc.citation.startpage | 8189 | - |
dc.citation.volume | 6 | - |
dc.identifier.sci | 000363017100016 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Chun, Jongsik | - |
dc.contributor.affiliatedAuthor | Lee, Junho | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | CAENORHABDITIS-ELEGANS | - |
dc.subject.keywordPlus | VARIANT REPEATS | - |
dc.subject.keywordPlus | DNA | - |
dc.subject.keywordPlus | RECOMBINATION | - |
dc.subject.keywordPlus | ABSENCE | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | ALIGNMENT | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | FUSIONS | - |
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