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Ferrimagnetic Nanochains-Based Mesenchymal Stem Cell Engineering for Highly Efficient Post-Stroke Recovery
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Zhang, Tianyuan | - |
dc.contributor.author | Li, Fangyuan | - |
dc.contributor.author | Xu, Qianhao | - |
dc.contributor.author | Wang, Qiyue | - |
dc.contributor.author | Jiang, Xinchi | - |
dc.contributor.author | Liang, Zeyu | - |
dc.contributor.author | Liao, Hongwei | - |
dc.contributor.author | Kong, Xianglei | - |
dc.contributor.author | Liu, Jianan | - |
dc.contributor.author | Wu, Honghui | - |
dc.contributor.author | Zhang, Danping | - |
dc.contributor.author | An, Changhua | - |
dc.contributor.author | Dong, Liang | - |
dc.contributor.author | Lu, Yang | - |
dc.contributor.author | Cao, Hongcui | - |
dc.contributor.author | Kim, Dokyoon | - |
dc.contributor.author | Sun, Jihong | - |
dc.contributor.author | Hyeon, Taeghwan | - |
dc.contributor.author | Gao, Jianqing | - |
dc.contributor.author | Ling, Daishun | - |
dc.date.accessioned | 2020-04-27T13:19:42Z | - |
dc.date.available | 2020-04-27T13:19:42Z | - |
dc.date.created | 2019-11-29 | - |
dc.date.issued | 2019-06 | - |
dc.identifier.citation | Advanced Functional Materials, Vol.29 No.24, p. 1900603 | - |
dc.identifier.issn | 1616-301X | - |
dc.identifier.other | 87311 | - |
dc.identifier.uri | https://hdl.handle.net/10371/165774 | - |
dc.description.abstract | Unsatisfactory post-stroke recovery has long been a negative factor in the prognosis of ischemic stroke due to the lack of pharmacological treatments. Mesenchymal stem cells (MSCs)-based therapy has recently emerged as a promising strategy redefining stroke treatment; however, its effectiveness has been largely restricted by insufficient therapeutic gene expression and inadequate cell numbers in the ischemic cerebrum. Herein, a non-viral and magnetic field-independent gene transfection approach is reported, using magnetosome-like ferrimagnetic iron oxide nanochains (MFIONs), to genetically engineer MSCs for highly efficient post-stroke recovery. The 1D MFIONs show efficient cellular uptake by MSCs, which results in highly efficient genetic engineering of MSCs to overexpress brain-derived neurotrophic factor for treating ischemic cerebrum. Moreover, the internalized MFIONs promote the homing of MSCs to the ischemic cerebrum by upregulating CXCR4. Consequently, a pronounced recovery from ischemic stroke is achieved using MFION-engineered MSCs in a mouse model. | - |
dc.language | 영어 | - |
dc.publisher | John Wiley & Sons Ltd. | - |
dc.title | Ferrimagnetic Nanochains-Based Mesenchymal Stem Cell Engineering for Highly Efficient Post-Stroke Recovery | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 현택환 | - |
dc.identifier.doi | 10.1002/adfm.201900603 | - |
dc.citation.journaltitle | Advanced Functional Materials | - |
dc.identifier.wosid | 000471074000006 | - |
dc.identifier.scopusid | 2-s2.0-85064448723 | - |
dc.citation.number | 24 | - |
dc.citation.startpage | 1900603 | - |
dc.citation.volume | 29 | - |
dc.identifier.sci | 000471074000006 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Hyeon, Taeghwan | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | MARROW STROMAL CELLS | - |
dc.subject.keywordPlus | GENE-THERAPY | - |
dc.subject.keywordPlus | MAGNETIC NANOPARTICLES | - |
dc.subject.keywordPlus | CEREBRAL-ISCHEMIA | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | TRACKING | - |
dc.subject.keywordPlus | TRANSFECTION | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordAuthor | ferrimagnetic iron oxide nanochains | - |
dc.subject.keywordAuthor | genetic engineering | - |
dc.subject.keywordAuthor | ischemic cerebrum homing | - |
dc.subject.keywordAuthor | mesenchymal stem cells | - |
dc.subject.keywordAuthor | post-stroke recovery | - |
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