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MR tracking of transplanted cells with "positive contrast" using manganese oxide nanoparticles
DC Field | Value | Language |
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dc.contributor.author | Gilad, Assaf A. | - |
dc.contributor.author | Walczak, Piotr | - |
dc.contributor.author | McMahon, Michael T. | - |
dc.contributor.author | Na, Hyon Bin | - |
dc.contributor.author | Lee, Jung Hee | - |
dc.contributor.author | An, Kwangjin | - |
dc.contributor.author | Hyeon, Taegwhan | - |
dc.contributor.author | van Zijl, Peter C. M. | - |
dc.contributor.author | Bulte, Jeff W. M. | - |
dc.date.accessioned | 2020-04-27T13:23:51Z | - |
dc.date.available | 2020-04-27T13:23:51Z | - |
dc.date.created | 2020-03-20 | - |
dc.date.issued | 2008-07 | - |
dc.identifier.citation | Magnetic Resonance in Medicine, Vol.60 No.1, pp.1-7 | - |
dc.identifier.issn | 0740-3194 | - |
dc.identifier.other | 92942 | - |
dc.identifier.uri | https://hdl.handle.net/10371/165830 | - |
dc.description.abstract | Rat glioma cells were labeled using electroporation with either manganese oxide (MnO) or superparamagnetic iron oxide (SPIO) nanoparticles. The viability and proliferation of SPIO-labeled cells (1.9 mg Fe/ml) or cells electroporated with a low dose of MnO (100 mu g Mn/ml) was not significantly different from unlabeled cells; a higher MnO dose (785 mu g Mn/ml) was found to be toxic. The cellular ion content was 0.1-0.3 pg Mn/cell and 4.4 pg Fe/cell, respectively, with cellular relaxivities of 2.5-4.8 s(-1) (RI) and 45-84 s(-1) (R-2) for MnO-labeled cells. Labeled cells (SPIO and low-dose MnO) were each transplanted in contralateral brain hemispheres of rats and imaged in vivo at 9.4T. While SPIO-labeled cells produced a strong "negative contrast" due to the increase in R-2, MnO-Iabeled cells produced "positive contrast" with an increased R-1. Simultaneous imaging of both transplants with opposite contrast offers a method for MR "double labeling" of different cell populations. | - |
dc.language | 영어 | - |
dc.publisher | John Wiley & Sons Inc. | - |
dc.title | MR tracking of transplanted cells with "positive contrast" using manganese oxide nanoparticles | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 현택환 | - |
dc.identifier.doi | 10.1002/mrm.21622 | - |
dc.citation.journaltitle | Magnetic Resonance in Medicine | - |
dc.identifier.wosid | 000257267700001 | - |
dc.identifier.scopusid | 2-s2.0-46849120034 | - |
dc.citation.endpage | 7 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 1 | - |
dc.citation.volume | 60 | - |
dc.identifier.sci | 000257267700001 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Hyeon, Taegwhan | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | NEURAL STEM-CELLS | - |
dc.subject.keywordPlus | AGENT | - |
dc.subject.keywordPlus | MAGNETOELECTROPORATION | - |
dc.subject.keywordPlus | PARTICLES | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordAuthor | manganese oxide | - |
dc.subject.keywordAuthor | iron oxide | - |
dc.subject.keywordAuthor | cellular imaging | - |
dc.subject.keywordAuthor | contrast agent | - |
dc.subject.keywordAuthor | transplantation | - |
dc.subject.keywordAuthor | nanoparticles | - |
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