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Therapeutic efficacy-potentiated and diseased organ-targeting nanovesicles derived from mesenchymal stem cells for spinal cord injury treatment
DC Field | Value | Language |
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dc.contributor.author | Kim, Han Young | - |
dc.contributor.author | Kumar, Hemant | - |
dc.contributor.author | Jo, Min-Jae | - |
dc.contributor.author | Kim, Jonghoon | - |
dc.contributor.author | Yoon, Jeong-Kee | - |
dc.contributor.author | Lee, Ju-Ro | - |
dc.contributor.author | Kang, Mikyung | - |
dc.contributor.author | Choo, Yeon Woong | - |
dc.contributor.author | Song, Seuk Young | - |
dc.contributor.author | Kwon, Sung Pil | - |
dc.contributor.author | Hyeon, Taeghwan | - |
dc.contributor.author | Han, In-Bo | - |
dc.contributor.author | Kim, Byung-Soo | - |
dc.date.accessioned | 2020-04-27T13:25:06Z | - |
dc.date.available | 2020-04-27T13:25:06Z | - |
dc.date.created | 2018-12-24 | - |
dc.date.issued | 2018-08 | - |
dc.identifier.citation | Nano Letters, Vol.18 No.8, pp.4965-4975 | - |
dc.identifier.issn | 1530-6984 | - |
dc.identifier.other | 71824 | - |
dc.identifier.uri | https://hdl.handle.net/10371/165844 | - |
dc.description.abstract | Human mesenchymal stem cell (hMSC)-derived exosomes have been spotlighted as a promising therapeutic agent for cell-free regenerative medicine. However, poor organ-targeting ability and insufficient therapeutic efficacy of systemically injected hMSC-exosomes were identified as critical limitations for their further applications. Therefore, in this study we fabricated iron oxide nanoparticle (IONP)-incorporated exosome-mimetic nanovesicles (NV-IONP) from IONP-treated hMSCs and evaluated their therapeutic efficacy in a clinically relevant model for spinal cord injury. Compared to exosome-mimetic nanovesicles (NV) prepared from untreated hMSCs, NV-IONP not only contained IONPs which act as a magnet-guided navigation tool but also carried greater amounts of therapeutic growth factors that can be delivered to the target cells. The increased amounts of therapeutic growth factors inside NV-IONP were attributed to IONPs that are slowly ionized to iron ions which activate the JNK and c-Jun signaling cascades in hMSCs. In vivo systemic injection of NV-IONP with magnetic guidance significantly increased the amount of NV-IONP accumulating in the injured spinal cord. Accumulated NV-IONP enhanced blood vessel formation, attenuated inflammation and apoptosis in the injured spinal cord, and consequently improved spinal cord function. Taken together, these findings highlight the development of therapeutic efficacy-potentiated extracellular nanovesicles and demonstrate their feasibility for repairing injured spinal cord. | - |
dc.language | 영어 | - |
dc.publisher | American Chemical Society | - |
dc.title | Therapeutic efficacy-potentiated and diseased organ-targeting nanovesicles derived from mesenchymal stem cells for spinal cord injury treatment | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 김병수 | - |
dc.contributor.AlternativeAuthor | 현택환 | - |
dc.identifier.doi | 10.1021/acs.nanolett.8b01816 | - |
dc.citation.journaltitle | Nano Letters | - |
dc.identifier.wosid | 000441478300048 | - |
dc.identifier.scopusid | 2-s2.0-85049909291 | - |
dc.citation.endpage | 4975 | - |
dc.citation.number | 8 | - |
dc.citation.startpage | 4965 | - |
dc.citation.volume | 18 | - |
dc.identifier.sci | 000441478300048 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Hyeon, Taeghwan | - |
dc.contributor.affiliatedAuthor | Kim, Byung-Soo | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | EXTRACELLULAR VESICLES | - |
dc.subject.keywordPlus | STROMAL CELLS | - |
dc.subject.keywordPlus | CONDITIONED MEDIUM | - |
dc.subject.keywordPlus | BONE-MARROW | - |
dc.subject.keywordPlus | C-JUN | - |
dc.subject.keywordPlus | EXOSOMES | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | BIODISTRIBUTION | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | COMMUNICATION | - |
dc.subject.keywordAuthor | Exosomes | - |
dc.subject.keywordAuthor | iron oxide nanoparticles | - |
dc.subject.keywordAuthor | mesenchymal stem cells | - |
dc.subject.keywordAuthor | nanovesicles | - |
dc.subject.keywordAuthor | spinal cord injury | - |
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