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Dynamic Nanoparticle Assemblies for Biomedical Applications

Cited 87 time in Web of Science Cited 95 time in Scopus
Authors
Li, Fangyuan; Lu, Jingxiong; Kong, Xueqian; Hyeon, Taeghwan; Ling, Daishun
Issue Date
2017-04
Citation
Advanced Materials, Vol.29 No.14, p. 1605897
Keywords
biomedical applicationnanomedicinenanoparticle assemblystimuli-responsivesurface ligands
Abstract
Designed synthesis and assembly of nanoparticles assisted by their surface ligands can create " smart" materials with programmed responses to external stimuli for biomedical applications. These assemblies can be designed to respond either exogenously (for example, to magnetic field, temperature, ultrasound, light, or electric pulses) or endogenously (to pH, enzymatic activity, or redox gradients) and play an increasingly important role in a diverse range of biomedical applications, such as biosensors, drug delivery, molecular imaging, and novel theranostic systems. In this review, the recent advances and challenges in the development of stimuli-responsive nanoparticle assemblies are summarized; in particular, the application-driven design of surface ligands for stimuli-responsive nanoparticle assemblies that are capable of sensing small changes in the disease microenvironment, which induce the related changes in their physico-chemical properties, is described. Finally, possible future research directions and problems that have to be addressed are briefly discussed.
ISSN
0935-9648
URI
http://hdl.handle.net/10371/165892
DOI
https://doi.org/10.1002/adma.201605897
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College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Chemical and Biological Engineering (화학생물공학부)Journal Papers (저널논문_화학생물공학부)
College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Chemical and Biological Engineering (화학생물공학부)Chemical Convergence for Energy and Environment (에너지환경 화학융합기술전공)Journal Papers (저널논문_에너지환경 화학융합기술전공)
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