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Continuous O-2-Evolving MnFe2O4 Nanoparticle-Anchored Mesoporous Silica Nanoparticles for Efficient Photodynamic Therapy in Hypoxic Cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jonghoon | - |
dc.contributor.author | Cho, Hye Rim | - |
dc.contributor.author | Jeon, Hyejin | - |
dc.contributor.author | Kim, Dokyoon | - |
dc.contributor.author | Song, Changyeong | - |
dc.contributor.author | Lee, Nohyun | - |
dc.contributor.author | Choi, Seung Hong | - |
dc.contributor.author | Hyeon, Taeghwan | - |
dc.date.accessioned | 2020-04-27T13:29:11Z | - |
dc.date.available | 2020-04-27T13:29:11Z | - |
dc.date.created | 2018-09-10 | - |
dc.date.issued | 2017-08 | - |
dc.identifier.citation | Journal of the American Chemical Society, Vol.139 No.32, pp.10992-10995 | - |
dc.identifier.issn | 0002-7863 | - |
dc.identifier.other | 52239 | - |
dc.identifier.uri | https://hdl.handle.net/10371/165907 | - |
dc.description.abstract | Therapeutic effects of photodynamic therapy (PDT) are limited by cancer hypoxia because the PDT process is dependent on O-2 concentration. Herein, we design biocompatible manganese ferrite nanoparticle-anchored mesoporous silica nanoparticles (MFMSNs) to overcome hypoxia, consequently enhancing the therapeutic efficiency of PDT. By exploiting the continuous O-2-evolving property of MnFe2O4 nanoparticles through the Fenton reaction, MFMSNs relieve hypoxic condition using a small amount of nanoparticles and improve therapeutic outcomes of PDT for tumors in vivo. In addition, MFMSNs exhibit T-2 contrast effect in magnetic resonance imaging (MRI), allowing in vivo tracking of MFMSNs. These findings demonstrate great potential of MFMSNs for theranostic agents in cancer therapy. | - |
dc.language | 영어 | - |
dc.publisher | American Chemical Society | - |
dc.title | Continuous O-2-Evolving MnFe2O4 Nanoparticle-Anchored Mesoporous Silica Nanoparticles for Efficient Photodynamic Therapy in Hypoxic Cancer | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 최승홍 | - |
dc.contributor.AlternativeAuthor | 현택환 | - |
dc.identifier.doi | 10.1021/jacs.7b05559 | - |
dc.citation.journaltitle | Journal of the American Chemical Society | - |
dc.identifier.wosid | 000408074800014 | - |
dc.identifier.scopusid | 2-s2.0-85027419941 | - |
dc.citation.endpage | 10995 | - |
dc.citation.number | 32 | - |
dc.citation.startpage | 10992 | - |
dc.citation.volume | 139 | - |
dc.identifier.sci | 000408074800014 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Choi, Seung Hong | - |
dc.contributor.affiliatedAuthor | Hyeon, Taeghwan | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | MANGANESE FERRITE NANOPARTICLES | - |
dc.subject.keywordPlus | TUMOR OXYGENATION | - |
dc.subject.keywordPlus | FENTON REACTION | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordPlus | ENHANCE | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | DOTS | - |
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