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Water-dispersible ferrimagnetic iron oxide nanocubes with extremely high r 2 relaxivity for highly sensitive in vivo MRI of tumors
DC Field | Value | Language |
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dc.contributor.author | Lee, Nohyun | - |
dc.contributor.author | Choi, Yoonseok | - |
dc.contributor.author | Lee, Youjin | - |
dc.contributor.author | Park, Mihyun | - |
dc.contributor.author | Moon, Woo Kyung | - |
dc.contributor.author | Choi, Seung Hong | - |
dc.contributor.author | Hyeon, Taeghwan | - |
dc.date.accessioned | 2020-04-27T13:51:57Z | - |
dc.date.available | 2020-04-27T13:51:57Z | - |
dc.date.created | 2020-03-17 | - |
dc.date.issued | 2012-06 | - |
dc.identifier.citation | Nano Letters, Vol.12 No.6, pp.3127-3131 | - |
dc.identifier.issn | 1530-6984 | - |
dc.identifier.other | 92746 | - |
dc.identifier.uri | https://hdl.handle.net/10371/166201 | - |
dc.description.abstract | The theoretically predicted maximum r(2) relaxivity of iron oxide nanoparticles was achieved by optimizing the overall size of ferrimagnetic iron oxide nanocubes. Uniform-sized iron oxide nanocubes with an edge length of 22 nm, encapsulated with PEG-phospholipids (WFION), exhibited high colloidal stability in aqueous media. In addition, WFIONs are biocompatible and did not affect cell viability at concentrations up to 0.75 mg Fe/ml. Owing to the enhanced colloidal stability and the high r(2) relaxivity (761 mM(-1) s(-1)), it was possible to successfully perform in vivo MR imaging of tumors by intravenous injection of 22-nm-sized WFIONs, using a clinical 3-T MR scanner. | - |
dc.language | 영어 | - |
dc.publisher | American Chemical Society | - |
dc.title | Water-dispersible ferrimagnetic iron oxide nanocubes with extremely high r 2 relaxivity for highly sensitive in vivo MRI of tumors | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 최승홍 | - |
dc.contributor.AlternativeAuthor | 문우경 | - |
dc.contributor.AlternativeAuthor | 현택환 | - |
dc.identifier.doi | 10.1021/nl3010308 | - |
dc.citation.journaltitle | Nano Letters | - |
dc.identifier.wosid | 000305106400079 | - |
dc.identifier.scopusid | 2-s2.0-84862272360 | - |
dc.citation.endpage | 3131 | - |
dc.citation.number | 6 | - |
dc.citation.startpage | 3127 | - |
dc.citation.volume | 12 | - |
dc.identifier.sci | 000305106400079 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Moon, Woo Kyung | - |
dc.contributor.affiliatedAuthor | Choi, Seung Hong | - |
dc.contributor.affiliatedAuthor | Hyeon, Taeghwan | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | STRONGLY MAGNETIZED SPHERES | - |
dc.subject.keywordPlus | CHEMICAL-EXCHANGE MODEL | - |
dc.subject.keywordPlus | CONTRAST AGENTS | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | FUNCTIONALIZATION | - |
dc.subject.keywordPlus | NANOCRYSTALS | - |
dc.subject.keywordPlus | PARTICLES | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | PROBES | - |
dc.subject.keywordAuthor | Nanoparticle | - |
dc.subject.keywordAuthor | nanomedicine | - |
dc.subject.keywordAuthor | iron oxide | - |
dc.subject.keywordAuthor | magnetic resonance imaging contrast agent | - |
dc.subject.keywordAuthor | colloidal stability | - |
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