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Non-coding RNAs shuttled via exosomes reshape the hypoxic tumor microenvironment

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Authors
Wang, Wenyu; Han, Youngjin; Jo, Hyun A; Lee, Juwon; Song, Yong Sang
Issue Date
2020-06-05
Publisher
BMC
Citation
Journal of Hematology & Oncology. 2020 Jun 05;13(1):67
Keywords
Exosomes, HypoxiaTumor microenvironmentMiRNALncRNANon-coding RNA
Abstract
Exosomes are small extracellular vesicles secreted by almost all the cells. Molecular cargos of exosomes can partially reflect the characteristics of originating cells. Exosome-mediated cell-to-cell interactions in the microenvironment are critical in cancer progression. Hypoxia, a key pro-cancerous feature of the tumor microenvironment, alters the releasing and contents of exosomes. A growing body of evidence shows that hypoxia induces more aggressive phenotypes in cancer. Of note, non-coding RNAs shuttled in hypoxic tumor-derived exosomes have been demonstrated as fundamental molecules in regulating cancer biology and remodeling tumor microenvironment. Furthermore, these hypoxic tumor-derived exosomal non-coding RNAs can be detected in the body fluids, serving as promising diagnostic and prognostic biomarkers. The current review discusses changes in cancer behaviors regulated by exosomes-secreted non-coding RNAs under hypoxic conditions.
ISSN
1756-8722
Language
English
URI
http://hdl.handle.net/10371/168611
DOI
https://doi.org/10.1186/s13045-020-00893-3
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)Journal Papers (저널논문_의학과)
College of Agriculture and Life Sciences (농업생명과학대학)Dept. of Agricultural Biotechnology (농생명공학부)Journal Papers (저널논문_농생명공학부)
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