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Altered presynaptic function and number of mitochondria in the medial prefrontal cortex of adult Cyfip2 heterozygous mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Gyu Hyun | - |
dc.contributor.author | Zhang, Yinhua | - |
dc.contributor.author | Kang, Hyae Rim | - |
dc.contributor.author | Lee, Seung-Hyun | - |
dc.contributor.author | Shin, Jiwon | - |
dc.contributor.author | Lee, Chan Hee | - |
dc.contributor.author | Kang, Hyojin | - |
dc.contributor.author | Ma, Ruiying | - |
dc.contributor.author | Jin, Chunmei | - |
dc.contributor.author | Kim, Yoonhee | - |
dc.contributor.author | Kim, Su Yeon | - |
dc.contributor.author | Kwon, Seok-Kyu | - |
dc.contributor.author | Choi, Se-Young | - |
dc.contributor.author | Lee, Kea Joo | - |
dc.contributor.author | Han, Kihoon | - |
dc.date.accessioned | 2020-09-18T10:44:18Z | - |
dc.date.available | 2020-09-18T19:50:52Z | - |
dc.date.issued | 2020-09-11 | - |
dc.identifier.citation | Molecular Brain, 13(1):123 | ko_KR |
dc.identifier.issn | 1756-6606 | - |
dc.identifier.uri | https://hdl.handle.net/10371/168949 | - |
dc.description.abstract | Variants of the cytoplasmic FMR1-interacting protein (CYFIP) gene family, CYFIP1 and CYFIP2, are associated with numerous neurodevelopmental and neuropsychiatric disorders. According to several studies, CYFIP1 regulates the development and function of both pre- and post-synapses in neurons. Furthermore, various studies have evaluated CYFIP2 functions in the postsynaptic compartment, such as regulating dendritic spine morphology; however, no study has evaluated whether and how CYFIP2 affects presynaptic functions. To address this issue, in this study, we have focused on the presynapses of layer 5 neurons of the medial prefrontal cortex (mPFC) in adult Cyfip2 heterozygous (Cyfip2+/−) mice. Electrophysiological analyses revealed an enhancement in the presynaptic short-term plasticity induced by high-frequency stimuli in Cyfip2+/− neurons compared with wild-type neurons. Since presynaptic mitochondria play an important role in buffering presynaptic Ca2+, which is directly associated with the short-term plasticity, we analyzed presynaptic mitochondria using electron microscopic images of the mPFC. Compared with wild-type mice, the number, but not the volume or cristae density, of mitochondria in both presynaptic boutons and axonal processes in the mPFC layer 5 of Cyfip2+/− mice was reduced. Consistent with an identification of mitochondrial proteins in a previously established CYFIP2 interactome, CYFIP2 was detected in a biochemically enriched mitochondrial fraction of the mouse mPFC. Collectively, these results suggest roles for CYFIP2 in regulating presynaptic functions, which may involve presynaptic mitochondrial changes. | ko_KR |
dc.description.sponsorship | This work was supported by the National Research Foundation of Korea
(NRF) grants funded by the Korea Government Ministry of Science and ICT (NRF-2018R1C1B6001235, NRF-2018M3C7A1024603, NRF-2017M3C7A1048086, and NRF-2020R1A2C3011464) and the KBRI Basic Research Programs (20-BR01-08 and 20-BR-04-01). | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BMC | ko_KR |
dc.subject | Presynapse | - |
dc.subject | Mitochondria | - |
dc.subject | Medial prefrontal cortex | - |
dc.subject | Cytoplasmic FMR1-interacting protein 2 | - |
dc.title | Altered presynaptic function and number of mitochondria in the medial prefrontal cortex of adult Cyfip2 heterozygous mice | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김규현 | - |
dc.contributor.AlternativeAuthor | 강혜림 | - |
dc.contributor.AlternativeAuthor | 이승현 | - |
dc.contributor.AlternativeAuthor | 신지원 | - |
dc.contributor.AlternativeAuthor | 이찬희 | - |
dc.contributor.AlternativeAuthor | 강효진 | - |
dc.contributor.AlternativeAuthor | 김윤희 | - |
dc.contributor.AlternativeAuthor | 김수연 | - |
dc.contributor.AlternativeAuthor | 권석규 | - |
dc.contributor.AlternativeAuthor | 최세영 | - |
dc.contributor.AlternativeAuthor | 이계주 | - |
dc.contributor.AlternativeAuthor | 한기훈 | - |
dc.identifier.doi | 10.1186/s13041-020-00668-4 | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2020-09-13T03:15:00Z | - |
dc.citation.number | 1 | ko_KR |
dc.citation.startpage | 123 | ko_KR |
dc.citation.volume | 13 | ko_KR |
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