Publications
Detailed Information
Recent advances in genome editing of stem cells for drug discovery and therapeutic application
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Jaesuk | - |
dc.contributor.author | Bayarsaikhan, Delger | - |
dc.contributor.author | Bayarsaikhan, Govigerel | - |
dc.contributor.author | Kim, Jin-Soo | - |
dc.contributor.author | Schwarzbach, Elizabeth | - |
dc.contributor.author | Lee, Bonghee | - |
dc.date.accessioned | 2021-01-31T03:08:21Z | - |
dc.date.available | 2021-01-31T03:08:21Z | - |
dc.date.created | 2020-05-12 | - |
dc.date.created | 2020-05-12 | - |
dc.date.issued | 2020-05 | - |
dc.identifier.citation | Pharmacology and Therapeutics, Vol.209, p. 107501 | - |
dc.identifier.issn | 0163-7258 | - |
dc.identifier.other | 99337 | - |
dc.identifier.uri | https://hdl.handle.net/10371/171741 | - |
dc.description.abstract | Genome engineering technologies right from viral vector-mediated to protein-based editing-which include zinc finger nucleases, TALENs, and CRISPR/Cas systems-have been improved significantly. These technologies have facilitated drug discovery and have resulted in the development of potential curative therapies for many intractable diseases. They can efficiently correct genetic errors; however, these technologies have limitations, such as off-target effects and possible safety issues, which need to be considered when employing these techniques in humans. Significant efforts have been made to overcome these limitations and to accelerate the clinical implementation of these technologies. In this review, we focus on the recent technological advancements in genome engineering and their applications in stem cells to enable efficient discovery of drugs and treatment of intractable diseases. (C) 2020 The Authors. Published by Elsevier Inc. | - |
dc.language | 영어 | - |
dc.publisher | Pergamon Press | - |
dc.title | Recent advances in genome editing of stem cells for drug discovery and therapeutic application | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 김진수 | - |
dc.identifier.doi | 10.1016/j.pharmthera.2020.107501 | - |
dc.citation.journaltitle | Pharmacology and Therapeutics | - |
dc.identifier.wosid | 000528248800008 | - |
dc.identifier.scopusid | 2-s2.0-85080937109 | - |
dc.citation.startpage | 107501 | - |
dc.citation.volume | 209 | - |
dc.identifier.sci | 000528248800008 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Kim, Jin-Soo | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ZINC-FINGER NUCLEASES | - |
dc.subject.keywordPlus | HUMAN HEMATOPOIETIC STEM | - |
dc.subject.keywordPlus | PROGENITOR CELLS | - |
dc.subject.keywordPlus | PROGRAMMABLE NUCLEASES | - |
dc.subject.keywordPlus | FANCONI-ANEMIA | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | RNA | - |
dc.subject.keywordPlus | DNA | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordAuthor | Genome editing | - |
dc.subject.keywordAuthor | Stem cells | - |
dc.subject.keywordAuthor | Drug discovery | - |
dc.subject.keywordAuthor | Therapeutic application | - |
- Appears in Collections:
- Files in This Item:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.