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Adenylation of maternally inherited MicroRNAs by wispy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Mihye | - |
dc.contributor.author | Choi, Yeon | - |
dc.contributor.author | Kim, Kijun | - |
dc.contributor.author | Jin, Hua | - |
dc.contributor.author | Lim, Jaechul | - |
dc.contributor.author | Tuan Anh Nguyen | - |
dc.contributor.author | Yang, Jihye | - |
dc.contributor.author | Jeong, Minsun | - |
dc.contributor.author | Giraldez, Antonio J. | - |
dc.contributor.author | Yang, Hui | - |
dc.contributor.author | Patel, Dinshaw J. | - |
dc.contributor.author | Kim, V. Narry | - |
dc.date.accessioned | 2021-01-31T08:13:02Z | - |
dc.date.available | 2021-01-31T08:13:02Z | - |
dc.date.created | 2020-07-16 | - |
dc.date.created | 2020-07-16 | - |
dc.date.created | 2020-07-16 | - |
dc.date.created | 2020-07-16 | - |
dc.date.created | 2020-07-16 | - |
dc.date.created | 2020-07-16 | - |
dc.date.created | 2020-07-16 | - |
dc.date.issued | 2014-12 | - |
dc.identifier.citation | Molecular Cell, Vol.56 No.5, pp.696-707 | - |
dc.identifier.issn | 1097-2765 | - |
dc.identifier.other | 107076 | - |
dc.identifier.uri | https://hdl.handle.net/10371/171909 | - |
dc.description.abstract | Early development depends heavily on accurate control of maternally inherited mRNAs, and yet it remains unknown how maternal microRNAs are regulated during maternal-to-zygotic transition (MZT). We here find that maternal microRNAs are highly adenylated at their 30 ends in mature oocytes and early embryos. Maternal microRNA adenylation is widely conserved in fly, sea urchin, and mouse. We identify Wispy, a noncanonical poly(A) polymerase, as the enzyme responsible for microRNA adenylation in flies. Knockout of wispy abrogates adenylation and results in microRNA accumulation in eggs, whereas overexpression of Wispy increases adenylation and reduces microRNA levels in S2 cells. Wispy interacts with Ago1 through protein-protein interaction, which may allow the effective and selective adenylation of microRNAs. Thus, adenylation may contribute to the clearance of maternally deposited microRNAs during MZT. Our work provides mechanistic insights into the regulation of maternal microRNAs and illustrates the importance of RNA tailing in development. | - |
dc.language | 영어 | - |
dc.publisher | Cell Press | - |
dc.title | Adenylation of maternally inherited MicroRNAs by wispy | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 김빛내리 | - |
dc.identifier.doi | 10.1016/j.molcel.2014.10.011 | - |
dc.citation.journaltitle | Molecular Cell | - |
dc.identifier.wosid | 000346653300010 | - |
dc.identifier.scopusid | 2-s2.0-84919482843 | - |
dc.citation.endpage | 707 | - |
dc.citation.number | 5 | - |
dc.citation.startpage | 696 | - |
dc.citation.volume | 56 | - |
dc.identifier.sci | 000346653300010 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Lim, Jaechul | - |
dc.contributor.affiliatedAuthor | Kim, V. Narry | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | MESSENGER-RNA TRANSLATION | - |
dc.subject.keywordPlus | TO-ZYGOTIC TRANSITION | - |
dc.subject.keywordPlus | POLY(A) POLYMERASE | - |
dc.subject.keywordPlus | CYTOPLASMIC POLYADENYLATION | - |
dc.subject.keywordPlus | EGG ACTIVATION | - |
dc.subject.keywordPlus | OOCYTE MATURATION | - |
dc.subject.keywordPlus | EMERGING ROLES | - |
dc.subject.keywordPlus | EARLY EMBRYOS | - |
dc.subject.keywordPlus | PRE-MICRORNA | - |
dc.subject.keywordPlus | DROSOPHILA | - |
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