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Conserved MicroRNA miR-8/miR-200 and Its Target USH/FOG2 Control Growth by Regulating PI3K
DC Field | Value | Language |
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dc.contributor.author | Hyun, Seogang | - |
dc.contributor.author | Lee, Jung Hyun | - |
dc.contributor.author | Jin, Hua | - |
dc.contributor.author | Nam, JinWu | - |
dc.contributor.author | Namkoong, Bumjin | - |
dc.contributor.author | Lee, Gina | - |
dc.contributor.author | Chung, Jongkyeong | - |
dc.contributor.author | Kim, V. Narry | - |
dc.date.accessioned | 2021-01-31T08:14:06Z | - |
dc.date.available | 2021-01-31T08:14:06Z | - |
dc.date.created | 2020-07-16 | - |
dc.date.issued | 2009-12 | - |
dc.identifier.citation | Cell, Vol.139 No.6, pp.1096-1108 | - |
dc.identifier.issn | 0092-8674 | - |
dc.identifier.other | 107022 | - |
dc.identifier.uri | https://hdl.handle.net/10371/171927 | - |
dc.description.abstract | How body size is determined is a long-standing question in biology, yet its regulatory mechanisms remain largely unknown. Here, we find that a conserved microRNA miR-8 and its target, USH, regulate body size in Drosophila. miR-8 null flies are smaller in size and defective in insulin signaling in fat body that is the fly counterpart of liver and adipose tissue. Fat body-specific expression and clonal analyses reveal that miR-8 activates PI3K, thereby promoting fat cell growth cell-autonomously and enhancing organismal growth non-cell-autonomously. Comparative analyses identify USH and its human homolog, FOG2, as the targets of fly miR-8 and human miR-200, respectively. USH/FOG2 inhibits PI3K activity, suppressing cell growth in both flies and humans. FOG2 directly binds to p85 alpha, the regulatory subunit of PI3K, and interferes with the formation of a PI3K complex. Our study identifies two novel regulators of insulin signaling, miR-8/miR-200 and USH/FOG2, and suggests their roles in adolescent growth, aging, and cancer. | - |
dc.language | 영어 | - |
dc.publisher | Cell Press | - |
dc.title | Conserved MicroRNA miR-8/miR-200 and Its Target USH/FOG2 Control Growth by Regulating PI3K | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 김빛내리 | - |
dc.identifier.doi | 10.1016/j.cell.2009.11.020 | - |
dc.citation.journaltitle | Cell | - |
dc.identifier.wosid | 000272622800012 | - |
dc.identifier.scopusid | 2-s2.0-71149108895 | - |
dc.citation.endpage | 1108 | - |
dc.citation.number | 6 | - |
dc.citation.startpage | 1096 | - |
dc.citation.volume | 139 | - |
dc.identifier.sci | 000272622800012 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Chung, Jongkyeong | - |
dc.contributor.affiliatedAuthor | Kim, V. Narry | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ZINC-FINGER PROTEINS | - |
dc.subject.keywordPlus | DROSOPHILA-MELANOGASTER | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTORS | - |
dc.subject.keywordPlus | PROTHORACIC GLAND | - |
dc.subject.keywordPlus | INSULIN | - |
dc.subject.keywordPlus | FOG-2 | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | FRIEND | - |
dc.subject.keywordPlus | SIZE | - |
dc.subject.keywordPlus | EXPRESSION | - |
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