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Chondroitin sulfate extracted from the Styela clava tunic suppresses TNF-α-induced expression of inflammatory factors, VCAM-1 and iNOS by blocking Akt/NF-κB signal in JB6 cells : Chondroitin sulfate extracted from the Styela clava tunic suppresses TNF-alpha-induced expression of inflammatory factors, VCAM-1 and NOS by blocking Akt/NF-kappa B signal in JB6 cells
Cited 42 time in
Web of Science
Cited 54 time in Scopus
- Authors
- Issue Date
- 2008-06
- Publisher
- Elsevier BV
- Citation
- Cancer Letters, Vol.264 No.1, pp.93-100
- Abstract
- Inflammatory mediators are known to play a key role in tumorigenesis, therefore, it is a promising strategy to inhibit the inflammation for cancer prevention and/or treatment. Current study was performed to investigate the effects of chondroitin sulfate (CS) extracted from Styela clava tunic on TNF-alpha-induced inflammation and to elucidate the mechanism of CS on the regulation of inflammatory factors in JB6 cells. Our results showed that CS inhibited TNF-alpha-induced NF-kappa B activation and subsequent vascular cell adhesion molecule 1 and inducible nitric oxide synthase expressions by blocking Akt signals in JB6 cells. Our results suggest that CS may be developed as an effective anti-inflammatory agent in the future. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
- ISSN
- 0304-3835
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