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Methylmercury induces caspase-dependent apoptosis and autophagy in human neural stem cells
DC Field | Value | Language |
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dc.contributor.author | Chang, Seung-Hee | - |
dc.contributor.author | Lee, Hong Jun | - |
dc.contributor.author | Kang, Bitna | - |
dc.contributor.author | Yu, Kyeong-Nam | - |
dc.contributor.author | Minai-Tehrani, Arash | - |
dc.contributor.author | Lee, Somin | - |
dc.contributor.author | Kim, Seung U. | - |
dc.contributor.author | Cho, Myung-Haing | - |
dc.date.accessioned | 2021-01-31T08:46:42Z | - |
dc.date.available | 2021-01-31T08:46:42Z | - |
dc.date.created | 2020-12-10 | - |
dc.date.issued | 2013-12 | - |
dc.identifier.citation | Journal of Toxicological Sciences, Vol.38 No.6, pp.823-831 | - |
dc.identifier.issn | 0388-1350 | - |
dc.identifier.other | 118954 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172447 | - |
dc.description.abstract | Methylmercury (MeHg) is a well-known human neurotoxic agent whose exposure sources are mainly environmental and aquatic-derived food. MeHg is reported to induce central nervous system disability. However, the exact mechanism of MeHg-induced neurotoxicity is still unknown. In this study, to investigate which cell death signaling pathway is related with MeHg-induced cytotoxicity, the effects of MeHg on apoptosis and autophagy were evaluated in HB1.F3 human neural stem cells (NSCs). Human NSCs were treated with 1 mu M of MeHg for 48 hr and the effect of MeHg on cell signaling pathway was elucidated. MeHg inhibited Akt1/mTOR signaling that led to induction of caspase-dependent apoptosis and autophagy in the NSCs. Furthermore, retinoic acid (RA)-induced neuronal differentiation was inhibited by MeHg. Taken together, these results suggest that MeHg inhibits the differentiation of human NSCs by induction of caspase-dependent apoptosis and autophagy. | - |
dc.language | 영어 | - |
dc.publisher | Japanese Society of Toxicological Sciences | - |
dc.title | Methylmercury induces caspase-dependent apoptosis and autophagy in human neural stem cells | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 조명행 | - |
dc.citation.journaltitle | Journal of Toxicological Sciences | - |
dc.identifier.wosid | 000328008100003 | - |
dc.identifier.scopusid | 2-s2.0-84887427376 | - |
dc.citation.endpage | 831 | - |
dc.citation.number | 6 | - |
dc.citation.startpage | 823 | - |
dc.citation.volume | 38 | - |
dc.identifier.sci | 000328008100003 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Cho, Myung-Haing | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordPlus | ACTIN | - |
dc.subject.keywordPlus | NEUROTOXICITY | - |
dc.subject.keywordPlus | NECROSIS | - |
dc.subject.keywordPlus | POLARITY | - |
dc.subject.keywordPlus | MERCURY | - |
dc.subject.keywordPlus | SIGNALS | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | CYTOSKELETON | - |
dc.subject.keywordAuthor | Methylmercury (MeHg) | - |
dc.subject.keywordAuthor | Human neural stem cell (NSC) | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.subject.keywordAuthor | Autophagy | - |
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