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Suppression of A549 lung cancer cell migration by precursor let-7g microRNA
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Sungjin | - |
dc.contributor.author | Minai-Tehrani, Arash | - |
dc.contributor.author | Xu, Cheng-Xiong | - |
dc.contributor.author | Chang, Seung-Hee | - |
dc.contributor.author | Woo, Min-Ah | - |
dc.contributor.author | Noh, Mi-Suk | - |
dc.contributor.author | Lee, Eun-Sun | - |
dc.contributor.author | Lim, Hwang-Tae | - |
dc.contributor.author | An, Gil-Hwan | - |
dc.contributor.author | Lee, Kee-Ho | - |
dc.contributor.author | Sung, Ha-Jung | - |
dc.contributor.author | Beck, George R., Jr. | - |
dc.contributor.author | Cho, Myung-Haing | - |
dc.date.accessioned | 2021-01-31T08:48:11Z | - |
dc.date.available | 2021-01-31T08:48:11Z | - |
dc.date.created | 2018-01-10 | - |
dc.date.issued | 2010-11 | - |
dc.identifier.citation | Molecular Medicine Reports, Vol.3 No.6, pp.1007-1013 | - |
dc.identifier.issn | 1791-2997 | - |
dc.identifier.other | 14351 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172473 | - |
dc.description.abstract | Let-7g miRNAs, short non-coding RNAs approximately 21 nucleotides long, repress protein translation by binding to the 3'UTR of target mRNAs. Aberrant expression of let-7g is associated with the poor prognosis of lung cancer patients. Compared to normal lung cells, let-7g expression is absent in non-small cell lung cancer (NSCLC) cells. Furthermore. K-Ras and HMGA2 are well known as targets of let-7g. In this study, we evaluated the potential role of precursor (pre)-let-7g in lung cancer cell metastasis, focusing on the two targets of let-7g, HMGA2 and K-Ras. We found that pre-let-7g inhibited the migration of A549 lung cancer cells through HMGA2-mediated E2F1 down-regulation. Thus, our results suggest that pre-let-7g could be used as a suitable target for the suppression of lung cancer cell migration. | - |
dc.language | 영어 | - |
dc.publisher | Spandidos Publications | - |
dc.title | Suppression of A549 lung cancer cell migration by precursor let-7g microRNA | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 조명행 | - |
dc.identifier.doi | 10.3892/mmr.2010.373 | - |
dc.citation.journaltitle | Molecular Medicine Reports | - |
dc.identifier.wosid | 000283383000018 | - |
dc.identifier.scopusid | 2-s2.0-78649479378 | - |
dc.citation.endpage | 1013 | - |
dc.citation.number | 6 | - |
dc.citation.startpage | 1007 | - |
dc.citation.volume | 3 | - |
dc.identifier.sci | 000283383000018 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Cho, Myung-Haing | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | GROUP-A PROTEINS | - |
dc.subject.keywordPlus | HEPATOCELLULAR-CARCINOMA | - |
dc.subject.keywordPlus | SELF-RENEWAL | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | HMGA2 | - |
dc.subject.keywordPlus | TARGETS | - |
dc.subject.keywordPlus | FAMILY | - |
dc.subject.keywordPlus | P53 | - |
dc.subject.keywordPlus | OVEREXPRESSION | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordAuthor | let-7g | - |
dc.subject.keywordAuthor | microRNA | - |
dc.subject.keywordAuthor | lung cancer cell migration | - |
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