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Modulation of cancer cell growth and progression by Caveolin-1 in the tumor microenvironment
DC Field | Value | Language |
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dc.contributor.author | Yoon, Hyo-Jin | - |
dc.contributor.author | Surh, Young-Joon | - |
dc.date.accessioned | 2021-01-31T09:17:33Z | - |
dc.date.available | 2021-01-31T09:17:33Z | - |
dc.date.created | 2020-12-10 | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Advances in Experimental Medicine and Biology, Vol.1277, pp.63-74 | - |
dc.identifier.issn | 0065-2598 | - |
dc.identifier.other | 118908 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172545 | - |
dc.description.abstract | Caveolin-1 (Cav-1), a major structural component of cell membrane caveolae, is involved in a variety of intracellular signaling pathways as well as transmembrane transport. Cav-1, as a scaffolding protein, modulates signal transduction associated with cell cycle progression, cellular senescence, cell proliferation and death, lipid homeostasis, etc. Cav-1 is also thought to regulate the expression or activity of oncoproteins, such as Src family kinases, H-Ras, protein kinase C, epidermal growth factor, extracellular signal-regulated kinase, and endothelial nitric oxide synthase. Because of its frequent overexpression or mutation in various tumor tissues and cancer cell lines, Cav-1 has been speculated to play a role as an oncoprotein in cancer development and progression. In contrast, Cav-1 may also function as a tumor suppressor, depending on the type of cancer cells and/or surrounding -stromal cells in the tumor microenvironment as well as the stage of tumors. | - |
dc.language | 영어 | - |
dc.publisher | Kluwer Academic/Plenum Publishers | - |
dc.title | Modulation of cancer cell growth and progression by Caveolin-1 in the tumor microenvironment | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1007/978-3-030-50224-9_4 | - |
dc.citation.journaltitle | Advances in Experimental Medicine and Biology | - |
dc.identifier.wosid | 000595856800005 | - |
dc.identifier.scopusid | 2-s2.0-85094936360 | - |
dc.citation.endpage | 74 | - |
dc.citation.startpage | 63 | - |
dc.citation.volume | 1277 | - |
dc.identifier.sci | 000595856800005 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.type.docType | Article; Book Chapter | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | EXPRESSION SUPPRESSES GROWTH | - |
dc.subject.keywordPlus | FOCAL ADHESION KINASE | - |
dc.subject.keywordPlus | MATRIX-METALLOPROTEINASE | - |
dc.subject.keywordPlus | COLON-CARCINOMA | - |
dc.subject.keywordPlus | METASTASIS | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | PERICYTES | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | TRANSFORMATION | - |
dc.subject.keywordAuthor | Caveolin-1 | - |
dc.subject.keywordAuthor | Caveolae | - |
dc.subject.keywordAuthor | Cancer-associated fibroblasts | - |
dc.subject.keywordAuthor | Cancer progression | - |
dc.subject.keywordAuthor | Cancer stem-like cells | - |
dc.subject.keywordAuthor | Epithelial-mesenchymal transition | - |
dc.subject.keywordAuthor | Metastasis | - |
dc.subject.keywordAuthor | Stem cells | - |
dc.subject.keywordAuthor | Stromal cells | - |
dc.subject.keywordAuthor | Tumor microenvironment | - |
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