Publications
Detailed Information
Lack of tumor promoting activity of capsaicin, a principal pungent ingredient of red pepper, in mouse skin carcinogenesis
Cited 41 time in
Web of Science
Cited 37 time in Scopus
- Authors
- Issue Date
- 1998-11
- Citation
- Anticancer Research, Vol.18 No.6A, pp.4201-4205
- Abstract
- Capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide) is the major pungent principle of hot peppers of the genus Capsicum. There have been numerous investigations to evaluate the effects of capsaicin on experimental carcinogenesis and mutagenesis, bur the results are discordant. In the present study, we have assessed the tumor promoting potential of capsaicin using a two stage mouse skin carcinogenesis model. Repeated applications of capsaicin (10 mu mol) onto the shaven back of female ICR mice following a single-initiation dose of 7,12-dimethylbenz[alpha]anthracene did not cause any significant increase- in papilloma formation and abnormal hyperplastic or inflammatory skin lesions, compared with the solvent control Furthermore, the topical application of capsaicin did not induce the epidermal ornithine decarboxylase activity, suggesting that it lacks tumor-promotional activity. On the contrary, the compound ameliorated the mouse skin carcinogenesis wizen given simultaneously with the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate.
- ISSN
- 0250-7005
- Files in This Item:
- There are no files associated with this item.
- Appears in Collections:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.