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15-Deoxy-Δ12,14-prostaglandin J2 as a potential endogenous regulator of redox-sensitive transcription factors : 15-deoxy-delta(12,14)-prostaglandin J(2) as a potential endogenous regulator of redox-sensitive transcription factors
DC Field | Value | Language |
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dc.contributor.author | Kim, Eun-Hee | - |
dc.contributor.author | Surh, Young-Joon | - |
dc.date.accessioned | 2021-01-31T09:21:40Z | - |
dc.date.available | 2021-01-31T09:21:40Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2006-11 | - |
dc.identifier.citation | Biochemical Pharmacology, Vol.72 No.11, pp.1516-1528 | - |
dc.identifier.issn | 0006-2952 | - |
dc.identifier.other | 3604 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172603 | - |
dc.description.abstract | 15-Deoxy-Delta(12,14)-prostaglandin J(2)(15d-PGJ(2)) has been known to display multifaceted cellular functions, including anti-inflammatory and cytoprotective effects. However, depending on the concentrations and intracellular microenvironment, this cyclopentenone prostaglandin can exert opposite effects. Because of the alpha,beta-unsaturated carbonyl moiety present in its cyclopentenone ring structure, 15d-PGJ(2) can act as a Michael reaction acceptor and readily interacts with critical cellular nucleophiles, such as cysteine thiol groups in proteins. Many of the biological effects induced by 15d-PGJ(2) involve redox-transcription factors as the potential targets. Thus, 15d-PGJ(2) can modulate the transcriptional activities of nuclear factor-kappa B (NF-kappa B), activator protein-1 (AP-1), nuclear factor-erythroid 2p45 (NF-E2)-related factors (Nrf2), hypoxia inducible factor (HIF), etc. 15d-PGJ(2) is also well known as an endogenous ligand of peroxisome proliferator-activated receptor gamma (PPAR gamma). However, the regulation of the aforementioned redox-sensitive transcription factors by 15d-PGJ(2) is not necessarily mediated via PPAR gamma activation, but rather involves covalent modification or oxidation of their critical cysteine residues acting as a redox-sensor. This commentary describes the biological and physiological functions of 15d-PGJ(2) and underlying biochemical and molecular mechanisms with emphasis on the modulation of redox-sensitive transcription factors and their regulators. (c) 2006 Elsevier Inc. All rights reserved. | - |
dc.language | 영어 | - |
dc.publisher | Elsevier BV | - |
dc.title | 15-Deoxy-Δ12,14-prostaglandin J2 as a potential endogenous regulator of redox-sensitive transcription factors | - |
dc.title.alternative | 15-deoxy-delta(12,14)-prostaglandin J(2) as a potential endogenous regulator of redox-sensitive transcription factors | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1016/j.bcp.2006.07.030 | - |
dc.citation.journaltitle | Biochemical Pharmacology | - |
dc.identifier.wosid | 000242310100018 | - |
dc.identifier.scopusid | 2-s2.0-33750530167 | - |
dc.citation.endpage | 1528 | - |
dc.citation.number | 11 | - |
dc.citation.startpage | 1516 | - |
dc.citation.volume | 72 | - |
dc.identifier.sci | 000242310100018 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | PROLIFERATOR-ACTIVATED RECEPTOR | - |
dc.subject.keywordPlus | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | HYPOXIA-INDUCIBLE FACTOR | - |
dc.subject.keywordPlus | PPAR-GAMMA AGONISTS | - |
dc.subject.keywordPlus | BREAST-CANCER CELLS | - |
dc.subject.keywordPlus | NITRIC-OXIDE SYNTHASE | - |
dc.subject.keywordPlus | SMOOTH-MUSCLE-CELLS | - |
dc.subject.keywordPlus | CYCLOPENTENONE PROSTAGLANDINS | - |
dc.subject.keywordPlus | CYCLOOXYGENASE-2 EXPRESSION | - |
dc.subject.keywordAuthor | 15-deoxy-Delta(12,14)-prostaglandin | - |
dc.subject.keywordAuthor | redox regulation | - |
dc.subject.keywordAuthor | thiol modification | - |
dc.subject.keywordAuthor | transcription factors | - |
dc.subject.keywordAuthor | PPAR-gamma | - |
dc.subject.keywordAuthor | NF-kappa B | - |
dc.subject.keywordAuthor | AP-1 | - |
dc.subject.keywordAuthor | Nrf2 | - |
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