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Hepatic DNA and RNA adduct formation from the carcinogen 7-hydroxymethyl-12-methylbenz[a]anthracene and its electrophilic sulfuric acid ester metabolite in preweanling rats and mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Surh, Young-Joon | - |
dc.contributor.author | Lai, Chen-Ching | - |
dc.contributor.author | Miller, James A. | - |
dc.contributor.author | Miller, Elizabeth C. | - |
dc.date.accessioned | 2021-01-31T09:22:23Z | - |
dc.date.available | 2021-01-31T09:22:23Z | - |
dc.date.created | 2019-10-18 | - |
dc.date.issued | 1987-04 | - |
dc.identifier.citation | Biochemical and Biophysical Research Communications, Vol.144 No.2, pp.576-582 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.other | 85289 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172614 | - |
dc.description.abstract | DNA and RNA adducts that were chromatographically identical to those formed in vitro on reaction of 7-sulfooxymethyl-12-methyl-benz[a]anthracene with guanine and adenine nucleosides were formed in the livers of rats and mice given i.p. injections of 7-hydroxymethyl- or 7-sulfooxymethyl-12-methylbenz[a]anthracene. Considerably higher levels of these hepatic adducts were obtained from the latter short-lived electrophilic ester than from the hydroxymethyl compound. These observations are consistent with the finding of rat liver cytosolic sulfotransferase activity for 7-hydroxymethyl-12-methylbenz[a]-anthracene (Watabe et al., Science 215, 403, 1982). Formation of these hepatic adducts from 7-hydroxymethyl-12-methylbenz[a]anthracene was inhibited by prior administration to rats of dehydroepiandrosterone, an inhibitor of the sulfotransferase activity for this hydroxymethyl hydrocarbon. © 1987 Academic Press, Inc. | - |
dc.language | 영어 | - |
dc.publisher | Academic Press | - |
dc.title | Hepatic DNA and RNA adduct formation from the carcinogen 7-hydroxymethyl-12-methylbenz[a]anthracene and its electrophilic sulfuric acid ester metabolite in preweanling rats and mice | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1016/S0006-291X(87)80005-0 | - |
dc.citation.journaltitle | Biochemical and Biophysical Research Communications | - |
dc.identifier.wosid | A1987H041000005 | - |
dc.identifier.scopusid | 2-s2.0-0023190875 | - |
dc.citation.endpage | 582 | - |
dc.citation.number | 2 | - |
dc.citation.startpage | 576 | - |
dc.citation.volume | 144 | - |
dc.identifier.sci | A1987H041000005 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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