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Enzymatic reduction of shogaol: A novel biotransformation pathway for the α,β-unsaturated ketone system : Enzymatic reduction of shogaol: A novel biotransformation pathway for the alpha, beta-unsaturated ketone system
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Surh, YJ | - |
dc.contributor.author | Lee, SS | - |
dc.date.accessioned | 2021-01-31T09:23:12Z | - |
dc.date.available | 2021-01-31T09:23:12Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 1992-06 | - |
dc.identifier.citation | Biochemistry International, Vol.27 No.1, pp.179-187 | - |
dc.identifier.issn | 0158-5231 | - |
dc.identifier.other | 5599 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172627 | - |
dc.description.abstract | A novel reductive metabolism of 1-(4-hydroxy-3-methoxyphenyl)-deca-4-ene-3-one (shogaol), a pungent principle of ginger, was investigated in rat liver in vitro. Ethyl acetate-extractable metabolites of shogaol formed by incubation of this alpha,beta-unsaturated ketone with rat liver cytosolic fraction fortified with NADPH or NADPH-generating system were isolated, and two major metabolites were identified as 1-(4-hydroxy-3-methoxyphenyl)-decan-3-one (paradol) and 1-(4-hydroxy-3-methoxy)-decan-3-ol (reduced paradol). 1-(4-hydroxy-3-methoxyphenyl)-deca-1-ene-3-one (dehydroparadol), a non-pungent analog of shogaol, formed the same metabolites as did shogaol under similar incubation conditions. Paradol appears to be an intermediate in the reductive metabolism of the alpha,beta-unsaturated ketone moiety of shogaol to the corresponding saturated alcohol. | - |
dc.language | 영어 | - |
dc.publisher | Academic Press | - |
dc.title | Enzymatic reduction of shogaol: A novel biotransformation pathway for the α,β-unsaturated ketone system | - |
dc.title.alternative | Enzymatic reduction of shogaol: A novel biotransformation pathway for the alpha, beta-unsaturated ketone system | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.citation.journaltitle | Biochemistry International | - |
dc.identifier.wosid | A1992HZ74300020 | - |
dc.identifier.scopusid | 2-s2.0-0026734484 | - |
dc.citation.endpage | 187 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 179 | - |
dc.citation.volume | 27 | - |
dc.identifier.sci | A1992HZ74300020 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Surh, YJ | - |
dc.contributor.affiliatedAuthor | Lee, SS | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | REDUCTASES | - |
dc.subject.keywordPlus | GINGEROL | - |
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