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Inhibitory effects of [6]-gingerol on PMA-induced COX-2 expression and activation of NF-κB and p38 MAPK in mouse skin : Inhibitory effects of [6]-gingerol on PMA-induced COX-2 expression and activation of NF-kappa B and p38 MAPK in mouse skin
DC Field | Value | Language |
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dc.contributor.author | Kim, Sue Ok | - |
dc.contributor.author | Chun, Kyung‐Soo | - |
dc.contributor.author | Kundu, Joydeb Kumar | - |
dc.contributor.author | Surh, Young‐Joon | - |
dc.date.accessioned | 2021-01-31T09:23:45Z | - |
dc.date.available | 2021-01-31T09:23:45Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2004 | - |
dc.identifier.citation | BioFactors, Vol.21 No.1-4, pp.27-31 | - |
dc.identifier.issn | 0951-6433 | - |
dc.identifier.other | 4288 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172636 | - |
dc.description.abstract | [6]-Gingerol, a major pungent ingredient of ginger (Zingiber officinale Roscoe, Zingiberaceae), has a wide array of pharmacologic effects. Previous studies have demonstrated that [6]-gingerol inhibits mouse skin tumor promotion and anchorage-independent growth of cultured mouse epidermal cells stimulated with epidermal growth factor. Cyclooxygenase-2 (COX-2), a key enzyme in the prostaglandin biosynthesis, has been recognized as a molecular target for many anti-inflammatory as well as chemopreventive agents. Topical application of [6]-gingerol inhibited phorbol 12-myristate 13-acetate -induced COX-2 expression. One of the essential transcription factors responsible for COX-2 induction is NF-kappaB. [6]-Gingerol suppressed NF-kappaB DNA binding activity in mouse skin. In addition, [6]-gingerol inhibited the phoshorylation of p38 mitogen-activated protein kinase which may account for its inactivation of NF-kappaB and suppression of COX-2 expression. | - |
dc.language | 영어 | - |
dc.publisher | International Union of Biochemistry by IRL Press | - |
dc.title | Inhibitory effects of [6]-gingerol on PMA-induced COX-2 expression and activation of NF-κB and p38 MAPK in mouse skin | - |
dc.title.alternative | Inhibitory effects of [6]-gingerol on PMA-induced COX-2 expression and activation of NF-kappa B and p38 MAPK in mouse skin | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1002/biof.552210107 | - |
dc.citation.journaltitle | BioFactors | - |
dc.identifier.wosid | 000227306700007 | - |
dc.identifier.scopusid | 2-s2.0-21544454944 | - |
dc.citation.endpage | 31 | - |
dc.citation.number | 1-4 | - |
dc.citation.startpage | 27 | - |
dc.citation.volume | 21 | - |
dc.identifier.sci | 000227306700007 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Surh, Young‐Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | MESSENGER-RNA STABILITY | - |
dc.subject.keywordPlus | PROTEIN-KINASE | - |
dc.subject.keywordPlus | CYCLOOXYGENASE-2 | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | DIETARY | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | CHEMOPREVENTION | - |
dc.subject.keywordPlus | PREVENTION | - |
dc.subject.keywordPlus | PATHWAYS | - |
dc.subject.keywordAuthor | chemoprevention | - |
dc.subject.keywordAuthor | cyclooxygenase-2 | - |
dc.subject.keywordAuthor | [6]-gingerol | - |
dc.subject.keywordAuthor | p38 MAPK | - |
dc.subject.keywordAuthor | NF-kappa B | - |
dc.subject.keywordAuthor | mouse skin | - |
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